Pemphigoid and Pemphigus Antigens in Cultured Epidermal Cells

Overview

Journal Br J Dermatol

Publisher Oxford University Press

Specialty Dermatology

Date 1978 Jun 1

PMID 354682

Citations 23

Authors

L A Diaz

C L Marcelo

Affiliations

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Abstract

Fractions of IgG from sera of patients with pemphigoid and pemphigus added to monolayer cultures of mouse epidermal cells resulted in a sparse distribution of cells. Direct immunofluorescence studies of these monolayers revealed epidermal cell surface antigens reacting with pemphigoid and pemphigus antibodies. We suggest that these antibodies may bind to epidermal cell surface antigenic molecules which are important in maintaining epidermal cell adhesion in culture.

Citing Articles

Bullous Pemphigoid IgG Induces Cell Dysfunction and Enhances the Motility of Epidermal Keratinocytes via Rac1/Proteasome Activation.

Tie D, Da X, Natsuga K, Yamada N, Yamamoto O, Morita E Front Immunol. 2019; 10:200.

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Involvement of the apoptotic mechanism in pemphigus foliaceus autoimmune injury of the skin.

Li N, Zhao M, Wang J, Liu Z, Diaz L J Immunol. 2008; 182(1):711-7.

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Identification and experimental verification of protective antigens against Streptococcus suis serotype 2 based on genome sequence analysis.

Liu L, Cheng G, Wang C, Pan X, Cong Y, Pan Q Curr Microbiol. 2008; 58(1):11-7.

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Advances in pemphigus and its endemic pemphigus foliaceus (Fogo Selvagem) phenotype: a paradigm of human autoimmunity.

Culton D, Qian Y, Li N, Rubenstein D, Aoki V, Filhio G J Autoimmun. 2008; 31(4):311-24.

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Expression of laminin, type IV procollagen and 230 kDa bullous pemphigoid antigen genes by keratinocytes and fibroblasts in culture: application of the polymerase chain reaction for detection of small amounts of messenger RNA.

Nomura K, Sugawara T, Sato T, Sawamura D, Hashimoto I, Sugita Y Arch Dermatol Res. 1994; 286(7):408-13.

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