in Native Americans in Northern Arizona

Overview

Journal Diseases

Date 2022 Apr 25

PMID 35466189

Authors

Fernando P Monroy

Heidi E Brown

Priscilla R Sanderson

Gregory Jarrin

Mimi Mbegbu

Shari Kyman

Robin B Harris

Affiliations

Soon will be listed here.

Abstract

Background: In Arizona prevalence of infection among Navajo adults is about 62% and gastric cancer incidence rate is 3-4 times higher than that of the non-Hispanic White population.

Aim: The aim of this study was to estimate the prevalence of specific virulence factors ( and ) among Navajo patients undergoing and their association with gastric disease.

Methods: Virulence genes, and in were investigated in gastric biopsies from 96 Navajo patients over age 18 who were undergoing esophagogastroduodenoscopy. Biopsies from the antrum and fundus were used for molecular characterization to determine type and number of EPIYA motifs and presence of alleles in the signal (s) and medium (m) regions of the gene.

Results: infection was found in 22.9% of the biopsy samples. The gene amplified in 57.6% of samples and showed a predominant "Western " type, with the EPIYA-ABC motif (45.4%), most prevalent. The allele s1bm1 was the most prevalent (54.5%).

Conclusions: genotypes were predominantly Western-type and ABC EPIYA motifs. The s1bm1 genotype was the most prevalent and seemed to be associated with gastritis. American Indian/Alaska Native populations are at higher risk for gastric cancer. It is important to identify genotypes of and virulence factors involved in the high prevalence of and associated disease among the Navajo population.

Citing Articles

Whole-genome sequencing of isolates from Native American gastric biopsy specimens.

Celona K, Williamson C, Dholakia R, Sahl J, Monroy F, Settles E Microbiol Resour Announc. 2024; 13(9):e0016024.

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The prevalence and risk factors of infection and virulence gene carriage in adults in the Navajo Nation.

Pete D, Salama N, Lampe J, Wu M, Phipps A Microbiota Health Dis. 2024; 6.

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Incidence of Stomach, Liver, and Colorectal Cancers by Geography and Social Vulnerability Among American Indian and Alaska Native Populations, 2010-2019.

Melkonian S, Jim M, Reza A, Peipins L, Haverkamp D, Said N Am J Epidemiol. 2023; 193(1):58-74.

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