D-Mannose Regulates Hepatocyte Lipid Metabolism PI3K/Akt/mTOR Signaling Pathway and Ameliorates Hepatic Steatosis in Alcoholic Liver Disease

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2022 Apr 25

PMID 35464439

Authors

Mengyao Hu

Yu Chen

Fan Deng

Bo Chang

Jialiang Luo

Lijun Dong

Xiao Lu

Yi Zhang

Zhengliang Chen

Jia Zhou

Affiliations

Soon will be listed here.

Abstract

This study investigated the protective properties and mechanisms of D-mannose against hepatic steatosis in experimental alcoholic liver disease (ALD). Drinking-water supplementation of D-mannose significantly attenuated hepatic steatosis in a standard mouse ALD model established by chronic-binge ethanol feeding, especially hepatocyte lipid deposition. This function of D-mannose on lipid accumulation in hepatocytes was also confirmed using ethanol-treated primary mouse hepatocytes (PMHs) with a D-mannose supplement. Meanwhile, D-mannose regulated lipid metabolism by rescuing ethanol-mediated reduction of fatty acid oxidation genes (PPARα, ACOX1, CPT1) and elevation of lipogenic genes (SREBP1c, ACC1, FASN). PI3K/Akt/mTOR signaling pathway was involved in this effect of D-mannose on lipid metabolism since PI3K/Akt/mTOR pathway inhibitors or agonists could abolish this effect in PMHs. Overall, our findings suggest that D-mannose exhibits its anti-steatosis effect in ALD by regulating hepatocyte lipid metabolism PI3K/Akt/mTOR signaling pathway.

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