Acts As a Tumor Suppressor in Nasopharyngeal Carcinoma by Suppressing the AKT/GSK3β/β-catenin Signaling Pathway

Overview

Journal Cytotechnology

Specialties Biotechnology
Genetics

Date 2022 Apr 25

PMID 35464163

Authors

Zhengyuan Yang

Xiajun Ye

Yujie Zhang

Yiteng Huang

Jian Chen

Yunzhu Zeng

Jiongyu Chen

Affiliations

Soon will be listed here.

Abstract

Supplementary Information: The online version contains supplementary material available at 10.1007/s10616-022-00520-8.

Citing Articles

Downregulation of ECRG4 by DNMT1 promotes EC growth via IRF3/IFN-γ/miR-29b/DNMT1/ECRG4 positive feedback loop.

Yang K, Chai S, Song H, Cao S, Gao F, Zhou C iScience. 2025; 28(1):111614.

PMID: 39834855 PMC: 11742825. DOI: 10.1016/j.isci.2024.111614.

The Recent Research Progress of NF-κB Signaling on the Proliferation, Migration, Invasion, Immune Escape and Drug Resistance of Glioblastoma.

Shi P, Xu J, Cui H Int J Mol Sci. 2023; 24(12).

PMID: 37373484 PMC: 10298967. DOI: 10.3390/ijms241210337.

Complex and pleiotropic signaling pathways regulated by the secreted protein augurin.

Richter M, Lalli E, Ruggiero C Cell Commun Signal. 2023; 21(1):69.

PMID: 37041625 PMC: 10088197. DOI: 10.1186/s12964-023-01090-8.

A potential link between aberrant expression of ECRG4 and atrial fibrillation.

Zhang Z, Wang W, Zhang Y, You X, Wu J Front Oncol. 2023; 13:1031128.

PMID: 36910669 PMC: 9992723. DOI: 10.3389/fonc.2023.1031128.

References

Yang X, Ma M, Sang M, Zhang X, Zou N, Zhu S . Knockdown of FAM83D Enhances Radiosensitivity in Coordination with Irradiation by Inhibiting EMT via the Akt/GSK-3β/Snail Signaling Pathway in Human Esophageal Cancer Cells. Onco Targets Ther. 2020; 13:4665-4678. PMC: 7263831. DOI: 10.2147/OTT.S245681. View

Liang X, Gao J, Wang Q, Hou S, Wu C . ECRG4 Represses Cell Proliferation and Invasiveness via NFIC/OGN/NF-κB Signaling Pathway in Bladder Cancer. Front Genet. 2020; 11:846. PMC: 7456849. DOI: 10.3389/fgene.2020.00846. View

Wang H, Chang Y, To K, Hwang J, Mai H, Feng Y . A new prognostic histopathologic classification of nasopharyngeal carcinoma. Chin J Cancer. 2016; 35:41. PMC: 4857443. DOI: 10.1186/s40880-016-0103-5. View

You Y, Yang W, Qin X, Wang F, Li H, Lin C . ECRG4 acts as a tumor suppressor and as a determinant of chemotherapy resistance in human nasopharyngeal carcinoma. Cell Oncol (Dordr). 2015; 38(3):205-14. DOI: 10.1007/s13402-015-0223-y. View

Deng P, Chang X, Gao Z, Xu X, Sun A, Li K . Downregulation and DNA methylation of ECRG4 in gastric cancer. Onco Targets Ther. 2018; 11:4019-4028. PMC: 6049055. DOI: 10.2147/OTT.S161200. View

Luo L, Wu J, Xie J, Xia L, Qian X, Cai Z . Downregulated ECRG4 is associated with poor prognosis in renal cell cancer and is regulated by promoter DNA methylation. Tumour Biol. 2015; 37(1):1121-9. DOI: 10.1007/s13277-015-3913-1. View

Pathmanathan R, Prasad U, Chandrika G, Sadler R, Flynn K, Raab-Traub N . Undifferentiated, nonkeratinizing, and squamous cell carcinoma of the nasopharynx. Variants of Epstein-Barr virus-infected neoplasia. Am J Pathol. 1995; 146(6):1355-67. PMC: 1870892. View

Chan A, Tao Q, Robertson K, Flinn I, Mann R, Klencke B . Azacitidine induces demethylation of the Epstein-Barr virus genome in tumors. J Clin Oncol. 2004; 22(8):1373-81. DOI: 10.1200/JCO.2004.04.185. View

Chen X, Liang R, Zhu X . Anti-EGFR therapies in nasopharyngeal carcinoma. Biomed Pharmacother. 2020; 131:110649. DOI: 10.1016/j.biopha.2020.110649. View

10.

Li L, Yu X, Yang Y, Zhang C, Guo L, Lu S . Expression of esophageal cancer related gene 4 (ECRG4), a novel tumor suppressor gene, in esophageal cancer and its inhibitory effect on the tumor growth in vitro and in vivo. Int J Cancer. 2009; 125(7):1505-13. DOI: 10.1002/ijc.24513. View

11.

Wang W, Fan H, Li X, Wu G, Zhao W, Zhang G . Beclin 1 promotes apoptosis and decreases invasion by upregulating the expression of ECRG4 in A549 human lung adenocarcinoma cells. Mol Med Rep. 2016; 14(1):355-60. DOI: 10.3892/mmr.2016.5219. View

12.

Dorschner R, Lee J, Cohen O, Costantini T, Baird A, Eliceiri B . ECRG4 regulates neutrophil recruitment and CD44 expression during the inflammatory response to injury. Sci Adv. 2020; 6(11):eaay0518. PMC: 7065879. DOI: 10.1126/sciadv.aay0518. View

13.

Ho H, Lin F, Chen P, Chen M, Hsin C, Yang S . Tricetin Suppresses Migration and Presenilin-1 Expression of Nasopharyngeal Carcinoma through Akt/GSK-3β Pathway. Am J Chin Med. 2020; 48(5):1203-1220. DOI: 10.1142/S0192415X20500597. View

14.

Chen Y, Chan A, Le Q, Blanchard P, Sun Y, Ma J . Nasopharyngeal carcinoma. Lancet. 2019; 394(10192):64-80. DOI: 10.1016/S0140-6736(19)30956-0. View

15.

Li L, Li X, Wang W, Gao T, Shi Z . UBE2C is involved in the functions of ECRG4 on esophageal squamous cell carcinoma. Biomed Pharmacother. 2017; 98:201-206. DOI: 10.1016/j.biopha.2017.12.066. View

16.

Xiang Z, Lv Q, Chen X, Zhu X, Liu S, Li D . Lnc GNG12-AS1 knockdown suppresses glioma progression through the AKT/GSK-3β/β-catenin pathway. Biosci Rep. 2020; 40(8). PMC: 7435023. DOI: 10.1042/BSR20201578. View

17.

Yang G, Wang Z, Chen Q, Zhang H, Lin X, Huang T . p53, latent membrane protein 1, bcl-2, and prognosis in nasopharyngeal carcinoma: a meta-analysis. Histol Histopathol. 2018; 34(2):103-110. DOI: 10.14670/HH-18-032. View

18.

Tian J, Zhang H, Mu L, Wang M, Li X, Zhang X . The miR-218/GAB2 axis regulates proliferation, invasion and EMT via the PI3K/AKT/GSK-3β pathway in prostate cancer. Exp Cell Res. 2020; 394(1):112128. DOI: 10.1016/j.yexcr.2020.112128. View

19.

Qin X, Zhang P . ECRG4: a new potential target in precision medicine. Front Med. 2018; 13(5):540-546. DOI: 10.1007/s11684-018-0637-9. View

20.

Peng L, Huang Y, Zhang F, Chen J, Huo X . Chronic cadmium exposure aggravates malignant phenotypes of nasopharyngeal carcinoma by activating the Wnt/β-catenin signaling pathway via hypermethylation of the casein kinase 1α promoter. Cancer Manag Res. 2018; 11:81-93. PMC: 6304082. DOI: 10.2147/CMAR.S171200. View