Non-Coding RNAs in Sepsis-Associated Acute Kidney Injury

Overview

Journal Front Physiol

Date 2022 Apr 25

PMID 35464083

Authors

Yanna Chen

Huan Jing

Simin Tang

Pei Liu

Ye Cheng

Youling Fan

Hongtao Chen

Jun Zhou

Affiliations

Soon will be listed here.

Abstract

Sepsis is a systemic inflammatory response caused by a severe infection that leads to multiple organ damage, including acute kidney injury (AKI). In intensive care units (ICU), the morbidity and mortality associated with sepsis-associated AKI (SA-AKI) are gradually increasing due to lack of effective and early detection, as well as proper treatment. Non-coding RNAs (ncRNAs) exert a regulatory function in gene transcription, RNA processing, post-transcriptional translation, and epigenetic regulation of gene expression. Evidence indicated that miRNAs are involved in inflammation and programmed cell death during the development of sepsis-associated AKI (SA-AKI). Moreover, lncRNAs and circRNAs appear to be an essential regulatory mechanism in SA-AKI. In this review, we summarized the molecular mechanism of ncRNAs in SA-AKI and discussed their potential in clinical diagnosis and treatment.

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