Recurrence in Malaria: a Prospective Cohort Study with Long Follow-up from a Coastal Region in South-West India

Overview

Journal F1000Res

Specialties Biomedical Engineering
Science

Date 2022 Apr 26

PMID 35464047

Authors

Divya Gandrala

Nitin Gupta

Alekhya Lavu

Vishnu Teja Nallapati

Vasudeva Guddattu

Kavitha Saravu

Affiliations

Soon will be listed here.

Abstract

India is endemic for malaria. Despite a decrease in incidence, its elimination is hampered by recurrences. This study aimed to characterize recurrences in malaria and study its association with primaquine (PQ) usage. Symptomatic adult patients were followed-up for up to 23 months for recurrences. The time to recurrence was compared by the PQ dosage they received using a log-rank test. Of the 294 malaria patients, 206 (70%) patients had infection during the study period. A total of 20 (9.7%) recurrences were seen in 17 (8.2%) patients of . The percentage of first-time recurrences were highest in the no PQ group (25%), followed by the weekly PQ group (20%), low dose daily PQ (8.2%) group, and high dose daily PQ group (3.1%). Recurrence in malaria is common, especially in those who receive an incorrect prescription of primaquine.

Citing Articles

Supervised administration of primaquine may enhance adherence to radical cure for malaria in India.

Rahi M, Sirohi P, Sharma A Lancet Reg Health Southeast Asia. 2023; 13:100199.

PMID: 37383547 PMC: 10305963. DOI: 10.1016/j.lansea.2023.100199.

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