The Multitubulin Hypothesis Revisited: What Have We Learned?

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 1987 Mar 1

PMID 3546332

Citations 43

Authors

D W Cleveland

Affiliations

Soon will be listed here.

Citing Articles

MAPping tubulin mutations.

Cushion T, Leca I, Keays D Front Cell Dev Biol. 2023; 11:1136699.

PMID: 36875768 PMC: 9975266. DOI: 10.3389/fcell.2023.1136699.

Microtubules in Microorganisms: How Tubulin Isotypes Contribute to Diverse Cytoskeletal Functions.

Bera A, Gupta Jr M Front Cell Dev Biol. 2022; 10:913809.

PMID: 35865635 PMC: 9294176. DOI: 10.3389/fcell.2022.913809.

Reconstituting Microtubules: A Decades-Long Effort From Building Block Identification to the Generation of Recombinant α/β-Tubulin.

Ti S Front Cell Dev Biol. 2022; 10:861648.

PMID: 35573669 PMC: 9096264. DOI: 10.3389/fcell.2022.861648.

β-Tubulin Isotype, TUBB4B, Regulates The Maintenance of Cancer Stem Cells.

Dharmapal D, Jyothy A, Mohan A, Balagopal P, George N, Sebastian P Front Oncol. 2022; 11:788024.

PMID: 35004310 PMC: 8733585. DOI: 10.3389/fonc.2021.788024.

Neuronal-Specific TUBB3 Is Not Required for Normal Neuronal Function but Is Essential for Timely Axon Regeneration.

Latremoliere A, Cheng L, Delisle M, Wu C, Chew S, Hutchinson E Cell Rep. 2018; 24(7):1865-1879.e9.

PMID: 30110642 PMC: 6155462. DOI: 10.1016/j.celrep.2018.07.029.

References

Serrano L, Avila J, Maccioni R . Controlled proteolysis of tubulin by subtilisin: localization of the site for MAP2 interaction. Biochemistry. 1984; 23(20):4675-81. DOI: 10.1021/bi00315a024. View

Sullivan K, Cleveland D . Sequence of a highly divergent beta tubulin gene reveals regional heterogeneity in the beta tubulin polypeptide. J Cell Biol. 1984; 99(5):1754-60. PMC: 2113369. DOI: 10.1083/jcb.99.5.1754. View

Gard D, Kirschner M . A polymer-dependent increase in phosphorylation of beta-tubulin accompanies differentiation of a mouse neuroblastoma cell line. J Cell Biol. 1985; 100(3):764-74. PMC: 2113523. DOI: 10.1083/jcb.100.3.764. View

Youngblom J, Schloss J, Silflow C . The two beta-tubulin genes of Chlamydomonas reinhardtii code for identical proteins. Mol Cell Biol. 1984; 4(12):2686-96. PMC: 369278. DOI: 10.1128/mcb.4.12.2686-2696.1984. View

Lewis S, Gilmartin M, Hall J, Cowan N . Three expressed sequences within the human beta-tubulin multigene family each define a distinct isotype. J Mol Biol. 1985; 182(1):11-20. DOI: 10.1016/0022-2836(85)90023-3. View

Bhattacharyya B, Sackett D, Wolff J . Tubulin, hybrid dimers, and tubulin S. Stepwise charge reduction and polymerization. J Biol Chem. 1985; 260(18):10208-16. View

Weatherbee J, May G, Gambino J, Morris N . Involvement of a particular species of beta-tubulin (beta 3) in conidial development in Aspergillus nidulans. J Cell Biol. 1985; 101(3):706-11. PMC: 2113703. DOI: 10.1083/jcb.101.3.706. View

Lewis S, Lee M, Cowan N . Five mouse tubulin isotypes and their regulated expression during development. J Cell Biol. 1985; 101(3):852-61. PMC: 2113702. DOI: 10.1083/jcb.101.3.852. View

Murphy D, Wallis K . Erythrocyte microtubule assembly in vitro. Determination of the effects of erythrocyte tau, tubulin isoforms, and tubulin oligomers on erythrocyte tubulin assembly, and comparison with brain microtubule assembly. J Biol Chem. 1985; 260(22):12293-301. View

10.

BOND J, Fridovich-Keil J, Pillus L, Mulligan R, Solomon F . A chicken-yeast chimeric beta-tubulin protein is incorporated into mouse microtubules in vivo. Cell. 1986; 44(3):461-8. DOI: 10.1016/0092-8674(86)90467-8. View

11.

Kirschner M, Mitchison T . Beyond self-assembly: from microtubules to morphogenesis. Cell. 1986; 45(3):329-42. DOI: 10.1016/0092-8674(86)90318-1. View

12.

Sullivan K, Cleveland D . Identification of conserved isotype-defining variable region sequences for four vertebrate beta tubulin polypeptide classes. Proc Natl Acad Sci U S A. 1986; 83(12):4327-31. PMC: 323725. DOI: 10.1073/pnas.83.12.4327. View

13.

Rothwell S, Grasser W, Murphy D . Tubulin variants exhibit different assembly properties. Ann N Y Acad Sci. 1986; 466:103-10. DOI: 10.1111/j.1749-6632.1986.tb38387.x. View

14.

Sullivan K, Lau J, Cleveland D . Apparent gene conversion between beta-tubulin genes yields multiple regulatory pathways for a single beta-tubulin polypeptide isotype. Mol Cell Biol. 1985; 5(9):2454-65. PMC: 366973. DOI: 10.1128/mcb.5.9.2454-2465.1985. View

15.

Sullivan K, Machlin P, Ratrie 3rd H, Cleveland D . Sequence and expression of the chicken beta 3 tubulin gene. A vertebrate testis beta-tubulin isotype. J Biol Chem. 1986; 261(28):13317-22. View

16.

Wang D, Villasante A, Lewis S, Cowan N . The mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype. J Cell Biol. 1986; 103(5):1903-10. PMC: 2114403. DOI: 10.1083/jcb.103.5.1903. View

17.

Adachi Y, Toda T, Niwa O, Yanagida M . Differential expressions of essential and nonessential alpha-tubulin genes in Schizosaccharomyces pombe. Mol Cell Biol. 1986; 6(6):2168-78. PMC: 367757. DOI: 10.1128/mcb.6.6.2168-2178.1986. View

18.

Villasante A, Wang D, Dobner P, Dolph P, Lewis S, Cowan N . Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis-specific expression of two sister genes. Mol Cell Biol. 1986; 6(7):2409-19. PMC: 367794. DOI: 10.1128/mcb.6.7.2409-2419.1986. View

19.

Schatz P, Pillus L, GRISAFI P, Solomon F, Botstein D . Two functional alpha-tubulin genes of the yeast Saccharomyces cerevisiae encode divergent proteins. Mol Cell Biol. 1986; 6(11):3711-21. PMC: 367132. DOI: 10.1128/mcb.6.11.3711-3721.1986. View

20.

Schatz P, Solomon F, Botstein D . Genetically essential and nonessential alpha-tubulin genes specify functionally interchangeable proteins. Mol Cell Biol. 1986; 6(11):3722-33. PMC: 367133. DOI: 10.1128/mcb.6.11.3722-3733.1986. View