Acute Type Adult T-cell Leukemia Cells Proliferate in the Lymph Nodes Rather Than in Peripheral Blood

Overview

Journal Cancer Gene Ther

Specialties Genetics
Oncology
Pharmacology

Date 2022 Apr 23

PMID 35459881

Authors

Mariko Mizuguchi

Mitsuyoshi Takatori

Shugo Sakihama

Manami Yoshita-Takahashi

Naoki Imaizumi

Yoshiaki Takahashi

Hiroo Hasegawa

Kennosuke Karube

Takuya Fukushima

Masataka Nakamura

Yuetsu Tanaka

Affiliations

Soon will be listed here.

Abstract

A massive increase in the number of mature CD4 T-cells in peripheral blood (PB) is a defining characteristic of acute type of adult T-cell leukemia (ATL). To date, the site of proliferation of ATL cells in the body has been unclear. In an attempt to address this question, we examined the expression of the proliferation marker, Ki-67, in freshly isolated ATL cells from PB and lymph nodes (LNs) of patients with various types of ATL. Our findings reveal that LN-ATL cells display higher expression of the Ki-67 antigen than PB-ATL cells in acute type patients. The gene expression of T-cell quiescence regulators such as Krüppel-like factor 2/6 and forkhead box protein 1 was substantially high in acute type PB-ATL cells. The expression of human telomerase reverse transcriptase, which is involved in T-cell expansion, was significantly low in PB-ATL cells from acute type patients, similar to that in normal resting T-cells. These findings suggest that ATL cells proliferate in the LNs rather than in PB.

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