Surface Plasmon Resonance (SPR) Spectroscopy and Photonic Integrated Circuit (PIC) Biosensors: A Comparative Review

Overview

Journal Sensors (Basel)

Publisher MDPI

Specialty Biotechnology

Date 2022 Apr 23

PMID 35458884

Authors

Patrick Steglich

Giulia Lecci

Andreas Mai

Affiliations

Soon will be listed here.

Abstract

Label-free direct-optical biosensors such as surface-plasmon resonance (SPR) spectroscopy has become a gold standard in biochemical analytics in centralized laboratories. Biosensors based on photonic integrated circuits (PIC) are based on the same physical sensing mechanism: evanescent field sensing. PIC-based biosensors can play an important role in healthcare, especially for point-of-care diagnostics, if challenges for a transfer from research laboratory to industrial applications can be overcome. Research is at this threshold, which presents a great opportunity for innovative on-site analyses in the health and environmental sectors. A deeper understanding of the innovative PIC technology is possible by comparing it with the well-established SPR spectroscopy. In this work, we shortly introduce both technologies and reveal similarities and differences. Further, we review some latest advances and compare both technologies in terms of surface functionalization and sensor performance.

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References

Qiu G, Gai Z, Tao Y, Schmitt J, Kullak-Ublick G, Wang J . Dual-Functional Plasmonic Photothermal Biosensors for Highly Accurate Severe Acute Respiratory Syndrome Coronavirus 2 Detection. ACS Nano. 2020; 14(5):5268-5277. DOI: 10.1021/acsnano.0c02439. View

Psarouli A, Botsialas A, Salapatas A, Stefanitsis G, Nikita D, Jobst G . Fast label-free detection of C-reactive protein using broad-band Mach-Zehnder interferometers integrated on silicon chips. Talanta. 2017; 165:458-465. DOI: 10.1016/j.talanta.2017.01.001. View

Banuls M, Puchades R, Maquieira A . Chemical surface modifications for the development of silicon-based label-free integrated optical (IO) biosensors: a review. Anal Chim Acta. 2013; 777:1-16. DOI: 10.1016/j.aca.2013.01.025. View

McClellan M, Domier L, Bailey R . Label-free virus detection using silicon photonic microring resonators. Biosens Bioelectron. 2011; 31(1):388-92. PMC: 3729447. DOI: 10.1016/j.bios.2011.10.056. View

Gomez-Gomez M, Sanchez C, Peransi S, Zurita D, Bellieres L, Recuero S . Photonic Label-Free Biosensors for Fast and Multiplex Detection of Swine Viral Diseases. Sensors (Basel). 2022; 22(3). PMC: 8838678. DOI: 10.3390/s22030708. View

Teng J, Dumon P, Bogaerts W, Zhang H, Jian X, Han X . Athermal Silicon-on-insulator ring resonators by overlaying a polymer cladding on narrowed waveguides. Opt Express. 2009; 17(17):14627-33. DOI: 10.1364/oe.17.014627. View

Pum J . A practical guide to validation and verification of analytical methods in the clinical laboratory. Adv Clin Chem. 2019; 90:215-281. DOI: 10.1016/bs.acc.2019.01.006. View

Vashist S, Schneider E, Barth E, Luong J . Surface plasmon resonance-based immunoassay for procalcitonin. Anal Chim Acta. 2016; 938:129-36. DOI: 10.1016/j.aca.2016.08.007. View

Walter J, Eilers A, Alwis L, Roth B, Bremer K . SPR Biosensor Based on Polymer Multi-Mode Optical Waveguide and Nanoparticle Signal Enhancement. Sensors (Basel). 2020; 20(10). PMC: 7287642. DOI: 10.3390/s20102889. View

10.

Zhou Z, Yin B, Michel J . Corrigendum: On-chip light sources for silicon photonics. Light Sci Appl. 2018; 5(4):e16098. PMC: 6059952. DOI: 10.1038/lsa.2016.98. View

11.

Abali F, Stevens M, Tibbe A, Terstappen L, van der Velde P, Schasfoort R . Isolation of single cells for protein therapeutics using microwell selection and Surface Plasmon Resonance imaging. Anal Biochem. 2017; 531:45-47. DOI: 10.1016/j.ab.2017.05.021. View

12.

Long F, Zhu A, Shi H . Recent advances in optical biosensors for environmental monitoring and early warning. Sensors (Basel). 2013; 13(10):13928-48. PMC: 3859100. DOI: 10.3390/s131013928. View

13.

Szymanska B, Lukaszewski Z, Hermanowicz-Szamatowicz K, Gorodkiewicz E . An immunosensor for the determination of carcinoembryonic antigen by Surface Plasmon Resonance imaging. Anal Biochem. 2020; 609:113964. DOI: 10.1016/j.ab.2020.113964. View

14.

Pelaez E, Estevez M, Mongui A, Menendez M, Toro C, Herrera-Sandoval O . Detection and Quantification of HspX Antigen in Sputum Samples Using Plasmonic Biosensing: Toward a Real Point-of-Care (POC) for Tuberculosis Diagnosis. ACS Infect Dis. 2020; 6(5):1110-1120. DOI: 10.1021/acsinfecdis.9b00502. View

15.

Robison H, Bailey R . A Guide to Quantitative Biomarker Assay Development using Whispering Gallery Mode Biosensors. Curr Protoc Chem Biol. 2017; 9(3):158-173. PMC: 5657521. DOI: 10.1002/cpch.23. View

16.

Schlachter C, Lisdat F, Frohme M, Erdmann V, Konthur Z, Lehrach H . Pushing the detection limits: the evanescent field in surface plasmon resonance and analyte-induced folding observation of long human telomeric repeats. Biosens Bioelectron. 2011; 31(1):571-4. DOI: 10.1016/j.bios.2011.11.003. View

17.

TalebiFard S, Schmidt S, Shi W, Wu W, Jaeger N, Kwok E . of Silicon-on-Insulator (SOI) strip waveguide resonator sensor. Biomed Opt Express. 2017; 8(2):500-511. PMC: 5330585. DOI: 10.1364/BOE.8.000500. View

18.

Pan M, Li S, Wang J, Sheng W, Wang S . Development and Validation of a Reproducible and Label-Free Surface Plasmon Resonance Immunosensor for Enrofloxacin Detection in Animal-Derived Foods. Sensors (Basel). 2017; 17(9). PMC: 5621032. DOI: 10.3390/s17091984. View

19.

Fernandez Gavela A, Grajales Garcia D, C Ramirez J, Lechuga L . Last Advances in Silicon-Based Optical Biosensors. Sensors (Basel). 2016; 16(3):285. PMC: 4813860. DOI: 10.3390/s16030285. View

20.

Schasfoort R, van Weperen J, van Amsterdam M, Parisot J, Hendriks J, Koerselman M . Presence and strength of binding of IgM, IgG and IgA antibodies against SARS-CoV-2 during CoViD-19 infection. Biosens Bioelectron. 2021; 183:113165. PMC: 7962981. DOI: 10.1016/j.bios.2021.113165. View