Serotonin Receptor Gene Polymorphisms Rs1985242 and Rs1062613, E-Cigarette Use and Personality

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2022 Apr 23

PMID 35457612

Authors

Aleksandra Suchanecka

Jolanta Chmielowiec

Krzysztof Chmielowiec

Grzegorz Trybek

Aleksandra Jaron

Wojciech Czarny

Pawel Krol

Jolanta Masiak

Anna Grzywacz

Affiliations

Soon will be listed here.

Abstract

We nowadays record growing numbers of e-cigarette users. The development of nicotine dependence is a result of many factors, including genetics and personality. In this study we analyzed two polymorphisms-rs1985242 and rs1062613-in the serotonin receptor gene in a group of e-cigarette users ( = 135) and controls ( = 106). Personality traits were measured using the NEO Five-Factor Inventory. The comparison of e-cigarette users with the control group indicates that the former showed significantly higher scores on the neuroticism scale and lower scores on the scales of extraversion and conscientiousness of the NEO-FFI. Homozygote variants of rs1985242 were more frequent in the study group. The results of the 2 × 3 factorial ANOVA for e-cigarette users and the control group as well as interaction between the rs1985242 variants were found for the NEO-FFI conscientiousness scale. These results allow us to conclude that the combination of psychological factors and genetic data creates a possibility for making more complete models of substance use disorders.

Citing Articles

Association of Polymorphism and Gene in People Addicted to Nicotine.

Chmielowiec K, Chmielowiec J, Stronska-Pluta A, Trybek G, Smiarowska M, Suchanecka A Int J Environ Res Public Health. 2022; 19(17).

PMID: 36078193 PMC: 9517777. DOI: 10.3390/ijerph191710478.

References

Enoch M, Gorodetsky E, Hodgkinson C, Roy A, Goldman D . Functional genetic variants that increase synaptic serotonin and 5-HT3 receptor sensitivity predict alcohol and drug dependence. Mol Psychiatry. 2010; 16(11):1139-46. PMC: 3003772. DOI: 10.1038/mp.2010.94. View

Henningfield J, Keenan R . Nicotine delivery kinetics and abuse liability. J Consult Clin Psychol. 1993; 61(5):743-50. DOI: 10.1037//0022-006x.61.5.743. View

Jang K, Lee S, Huh H, Chae J . Influence of the 5-HT3A Receptor Gene Polymorphism and Childhood Sexual Trauma on Central Serotonin Activity. PLoS One. 2015; 10(12):e0145269. PMC: 4689356. DOI: 10.1371/journal.pone.0145269. View

Vansickel A, Eissenberg T . Electronic cigarettes: effective nicotine delivery after acute administration. Nicotine Tob Res. 2012; 15(1):267-70. PMC: 3524053. DOI: 10.1093/ntr/ntr316. View

Breitinger H, Geetha N, Hess G . Inhibition of the serotonin 5-HT3 receptor by nicotine, cocaine, and fluoxetine investigated by rapid chemical kinetic techniques. Biochemistry. 2001; 40(28):8419-29. DOI: 10.1021/bi0106890. View

Walstab J, Rappold G, Niesler B . 5-HT(3) receptors: role in disease and target of drugs. Pharmacol Ther. 2010; 128(1):146-69. DOI: 10.1016/j.pharmthera.2010.07.001. View

Oreland L, Lagravinese G, Toffoletto S, Nilsson K, Harro J, Cloninger C . Personality as an intermediate phenotype for genetic dissection of alcohol use disorder. J Neural Transm (Vienna). 2017; 125(1):107-130. PMC: 5754455. DOI: 10.1007/s00702-016-1672-9. View

Carboni E, Acquas E, Frau R, Di Chiara G . Differential inhibitory effects of a 5-HT3 antagonist on drug-induced stimulation of dopamine release. Eur J Pharmacol. 1989; 164(3):515-9. DOI: 10.1016/0014-2999(89)90259-8. View

Seneviratne C, Franklin J, Beckett K, Ma J, Ait-Daoud N, Payne T . Association, interaction, and replication analysis of genes encoding serotonin transporter and 5-HT3 receptor subunits A and B in alcohol dependence. Hum Genet. 2013; 132(10):1165-76. PMC: 3775919. DOI: 10.1007/s00439-013-1319-y. View

10.

Petry N, Stinson F, Grant B . Comorbidity of DSM-IV pathological gambling and other psychiatric disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. J Clin Psychiatry. 2005; 66(5):564-74. DOI: 10.4088/jcp.v66n0504. View

11.

Pietras T, Witusik A, Panek M, Szemraj J, Gorski P . Anxiety, depression and methods of stress coping in patients with nicotine dependence syndrome. Med Sci Monit. 2011; 17(5):CR272-6. PMC: 3539593. DOI: 10.12659/msm.881767. View

12.

Sharp B, Chen H . Neurogenetic determinants and mechanisms of addiction to nicotine and smoked tobacco. Eur J Neurosci. 2018; 50(3):2164-2179. DOI: 10.1111/ejn.14171. View

13.

Samaha A, Yau W, Yang P, Robinson T . Rapid delivery of nicotine promotes behavioral sensitization and alters its neurobiological impact. Biol Psychiatry. 2005; 57(4):351-60. DOI: 10.1016/j.biopsych.2004.11.040. View

14.

Sai K, Zuo Y, Rose J, Garg P, Garg S, Nazih R . Rapid Brain Nicotine Uptake from Electronic Cigarettes. J Nucl Med. 2019; 61(6):928-930. PMC: 8008769. DOI: 10.2967/jnumed.119.230748. View

15.

Zilberman N, Yadid G, Efrati Y, Neumark Y, Rassovsky Y . Personality profiles of substance and behavioral addictions. Addict Behav. 2018; 82:174-181. DOI: 10.1016/j.addbeh.2018.03.007. View

16.

Adan A, Forero D, Navarro J . Personality Traits Related to Binge Drinking: A Systematic Review. Front Psychiatry. 2017; 8:134. PMC: 5532381. DOI: 10.3389/fpsyt.2017.00134. View

17.

Grzywacz A, Suchanecka A, Chmielowiec J, Chmielowiec K, Szumilas K, Masiak J . Personality Traits or Genetic Determinants-Which Strongly Influences E-Cigarette Users?. Int J Environ Res Public Health. 2020; 17(1). PMC: 6981659. DOI: 10.3390/ijerph17010365. View

18.

DeYoung C, Hirsh J, Shane M, Papademetris X, Rajeevan N, Gray J . Testing predictions from personality neuroscience. Brain structure and the big five. Psychol Sci. 2010; 21(6):820-8. PMC: 3049165. DOI: 10.1177/0956797610370159. View

19.

Allain F, Minogianis E, Roberts D, Samaha A . How fast and how often: The pharmacokinetics of drug use are decisive in addiction. Neurosci Biobehav Rev. 2015; 56:166-79. DOI: 10.1016/j.neubiorev.2015.06.012. View

20.

Sutin A, Terracciano A, Deiana B, Uda M, Schlessinger D, Lakatta E . Cholesterol, triglycerides, and the Five-Factor Model of personality. Biol Psychol. 2010; 84(2):186-91. PMC: 2933037. DOI: 10.1016/j.biopsycho.2010.01.012. View