Intestinal Alkaline Phosphatase: A Review of This Enzyme Role in the Intestinal Barrier Function

Overview

Journal Microorganisms

Specialty Microbiology

Date 2022 Apr 23

PMID 35456797

Authors

Gilberto Maia Santos

Shamila Ismael

Juliana Morais

Joao R Araujo

Ana Faria

Conceicao Calhau

Claudia Marques

Affiliations

Soon will be listed here.

Abstract

Intestinal alkaline phosphatase (IALP) has recently assumed a special relevance, being the subject of study in the prevention and treatment of certain diseases related to leaky gut. This brush border enzyme (ecto-enzyme) plays an important role in the maintenance of intestinal microbial homeostasis and intestinal barrier function through its ability to dephosphorylate lipopolysaccharide (LPS). This review addresses how IALP and intestinal barrier dysfunction may be implicated in the pathophysiology of specific diseases such as inflammatory bowel disease, necrotizing enterocolitis, and metabolic syndrome. The use of IALP as a possible biomarker to assess intestinal barrier function and strategies to modulate IALP activity are also discussed.

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