First Record of Spp. in Alpine Wild Rodents: Implications and Perspectives for Transmission Dynamics Across the Food Web

Overview

Journal Microorganisms

Specialty Microbiology

Date 2022 Apr 23

PMID 35456763

Authors

Giulia Ferrari

Matteo Girardi

Francesca Cagnacci

Olivier Devineau

Valentina Tagliapietra

Affiliations

Soon will be listed here.

Abstract

Among the Apicomplexa parasites, spp. have been mainly studied in domestic animals and peri-urban areas. The epidemiology of spp. is poorly investigated in natural systems and wild hosts because of their scarce veterinary and economic relevance. For most habitats, the occurrence of these parasites is unknown, despite their high ecosystemic role. To fill this gap for alpine small mammals, we applied molecular PCR-based methods and sequencing to determine the spp. in 830 ear samples from 11 small mammal species (i.e., , , , , and genera) live-trapped during a cross-sectional study along an altitudinal gradient in the North-Eastern Italian Alps. We detected spp. with an overall prevalence of 35.9%. Two species ranging from 500 m a.s.l. to 2500 m a.s.l. were the most infected: , followed by spp. Additionally, we detected the parasite for the first time in another alpine species: at 2000-2500 m a.s.l. Our findings suggest that several rodent species maintain spp. along the alpine altitudinal gradient of habitats. The transmission pathway of this group of parasites and their role within the alpine mammal community need further investigation, especially in consideration of the rapidly occurring environmental and climatic changes.

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References

Galfsky D, Krol N, Pfeffer M, Obiegala A . Long-term trends of tick-borne pathogens in regard to small mammal and tick populations from Saxony, Germany. Parasit Vectors. 2019; 12(1):131. PMC: 6434846. DOI: 10.1186/s13071-019-3382-2. View

Duscher G, Leschnik M, Fuehrer H, Joachim A . Wildlife reservoirs for vector-borne canine, feline and zoonotic infections in Austria. Int J Parasitol Parasites Wildl. 2015; 4(1):88-96. PMC: 4356739. DOI: 10.1016/j.ijppaw.2014.12.001. View

Gimenez C, Casado N, Criado-Fornelio A, de Miguel F, Dominguez-Penafiel G . A molecular survey of Piroplasmida and Hepatozoon isolated from domestic and wild animals in Burgos (northern Spain). Vet Parasitol. 2009; 162(1-2):147-50. DOI: 10.1016/j.vetpar.2009.02.021. View

Zechmeisterova K, Javanbakht H, Kvicerova J, Siroky P . Against growing synonymy: Identification pitfalls of Hepatozoon and Schellackia demonstrated on North Iranian reptiles. Eur J Protistol. 2021; 79:125780. DOI: 10.1016/j.ejop.2021.125780. View

Casati S, Sager H, Gern L, Piffaretti J . Presence of potentially pathogenic Babesia sp. for human in Ixodes ricinus in Switzerland. Ann Agric Environ Med. 2006; 13(1):65-70. View

Maia J, Alvares F, Boratynski Z, Brito J, Leite J, Harris D . Molecular assessment of Hepatozoon (Apicomplexa: Adeleorina) infections in wild canids and rodents from north Africa, with implications for transmission dynamics across taxonomic groups. J Wildl Dis. 2014; 50(4):837-48. DOI: 10.7589/2013-10-280. View

Healing T . Infections with blood parasites in the small British rodents Apodemus sylvaticus, Clethrionomys glareolus and Microtus agrestis. Parasitology. 1981; 83(Pt 1):179-89. DOI: 10.1017/s0031182000050149. View

Pacifico L, Braff J, Buono F, Beall M, Neola B, Buch J . Hepatozoon canis in hunting dogs from Southern Italy: distribution and risk factors. Parasitol Res. 2020; 119(9):3023-3031. PMC: 7431440. DOI: 10.1007/s00436-020-06820-2. View

Battisti E, Zanet S, Khalili S, Trisciuoglio A, Hertel B, Ferroglio E . Molecular Survey on Vector-Borne Pathogens in Alpine Wild Carnivorans. Front Vet Sci. 2020; 7:1. PMC: 6989405. DOI: 10.3389/fvets.2020.00001. View

10.

Dahmana H, Granjon L, Diagne C, Davoust B, Fenollar F, Mediannikov O . Rodents as Hosts of Pathogens and Related Zoonotic Disease Risk. Pathogens. 2020; 9(3). PMC: 7157691. DOI: 10.3390/pathogens9030202. View

11.

White R, Razgour O . Emerging zoonotic diseases originating in mammals: a systematic review of effects of anthropogenic land-use change. Mamm Rev. 2020; 50(4):336-352. PMC: 7300897. DOI: 10.1111/mam.12201. View

12.

Irwin D, Kocher T, Wilson A . Evolution of the cytochrome b gene of mammals. J Mol Evol. 1991; 32(2):128-44. DOI: 10.1007/BF02515385. View

13.

LARKIN M, Blackshields G, Brown N, Chenna R, McGettigan P, McWilliam H . Clustal W and Clustal X version 2.0. Bioinformatics. 2007; 23(21):2947-8. DOI: 10.1093/bioinformatics/btm404. View

14.

Duscher G, Fuehrer H, Kubber-Heiss A . Fox on the run--molecular surveillance of fox blood and tissue for the occurrence of tick-borne pathogens in Austria. Parasit Vectors. 2014; 7:521. PMC: 4243377. DOI: 10.1186/s13071-014-0521-7. View

15.

Helm C, von Samson-Himmelstjerna G, Liesner J, Kohn B, Muller E, Schaper R . Identical 18S rRNA haplotypes of Hepatozoon canis in dogs and foxes in Brandenburg, Germany. Ticks Tick Borne Dis. 2020; 11(6):101520. DOI: 10.1016/j.ttbdis.2020.101520. View

16.

Rizzoli A, Tagliapietra V, Cagnacci F, Marini G, Arnoldi D, Rosso F . Parasites and wildlife in a changing world: The vector-host- pathogen interaction as a learning case. Int J Parasitol Parasites Wildl. 2019; 9:394-401. PMC: 6630057. DOI: 10.1016/j.ijppaw.2019.05.011. View

17.

Grillini M, Simonato G, Tessarin C, Dotto G, Traversa D, Cassini R . sp. and spp. in Domestic Cats: A Preliminary Study in North-Eastern Italy. Pathogens. 2021; 10(9). PMC: 8468074. DOI: 10.3390/pathogens10091214. View

18.

Squarre D, Nakamura Y, Hayashida K, Kawai N, Chambaro H, Namangala B . Investigation of the piroplasm diversity circulating in wildlife and cattle of the greater Kafue ecosystem, Zambia. Parasit Vectors. 2020; 13(1):599. PMC: 7708252. DOI: 10.1186/s13071-020-04475-7. View

19.

Murata T, Inoue M, Tateyama S, Taura Y, Nakama S . Vertical transmission of Hepatozoon canis in dogs. J Vet Med Sci. 1993; 55(5):867-8. DOI: 10.1292/jvms.55.867. View

20.

Simpson V, Birtles R, Bown K, Panciera R, Butler H, Davison N . Hepatozoon species infection in wild red squirrels (Sciurus vulgaris) on the Isle of Wight. Vet Rec. 2006; 159(7):202-5. DOI: 10.1136/vr.159.7.202. View