Genetic Variations and MRNA Expression of Goat and Their Associations with Litter Size

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2022 Apr 23

PMID 35456050

Authors

Zhen Wang

Ruolan Wang

Chuanying Pan

Hong Chen

Lei Qu

Lian Wu

Zhengang Guo

Haijing Zhu

Xianyong Lan

Affiliations

Soon will be listed here.

Abstract

Dynein Axonemal Heavy Chain 1 (DNAH1) encodes proteins which provide structural support for the physiological function and motor structure of spermatozoa (hereafter referred to as sperm) and ova. This study found that three single nucleotide polymorphisms (SNPs), the 27-bp insertion/deletion (InDel) mutations and three exonic copy number variations (CNVs) within DNAH1 were significantly associated with litter size of Shaanbei white cashmere goats (n = 1101). Goats with the wildtypes of these three SNPs had higher litter sizes than other carriers (p < 0.05). II genotype of the 27-bp InDel had the highest litter size compared with ID carriers (p = 0.000022). The gain genotype had the largest litter sizes compared with the loss or medium carriers for the three CNV mutations (p < 0.01). Individuals with the AA-TT-CC-II-M1-M2-M3 and AA-TT-CC-II-G1-G2-M3 combination genotypes had larger litter sizes compared with the other genotypes. This study also showed the DNAH1 expression in mothers of multiple kids was higher than mothers of single kids. These three SNPs, the 27-bp InDel and three CNVs in DNAH1 could be used as molecular markers for the selection of goat reproductive traits.

Citing Articles

Potential Candidate Genes Associated with Litter Size in Goats: A Review.

Chen W, Han Y, Chen Y, Liu X, Liang H, Wang C Animals (Basel). 2025; 15(1.

PMID: 39795025 PMC: 11718837. DOI: 10.3390/ani15010082.

Genome-Wide DNA Methylation Analysis and Functional Validation of Litter Size Traits in Jining Grey Goats.

Yang C, He J, Mao J, Ren Y, Liu G, Wei C Genes (Basel). 2024; 15(3).

PMID: 38540412 PMC: 10970512. DOI: 10.3390/genes15030353.

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