Fibroblast Growth Factor Enhances the Interleukin-1-mediated Chondrocytic Protease Release

Overview

Journal Biochem Biophys Res Commun

Publisher Elsevier

Specialty Biochemistry

Date 1987 Jan 30

PMID 3545206

Citations 7

Authors

K Phadke

Affiliations

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Abstract

The unfractionated macrophage-conditioned medium stimulates the chondrocytes to produce high levels of proteases. Purified IL-1 preparations exhibit significantly lower activity towards chondrocytes. This IL-1 mediated effect can be enhanced in presence of fibroblast growth factor, suggesting that other factors may collaborate with IL-1, in events leading to the cartilage destruction in vivo.

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