The Efficacy and Safety of Massage Adjuvant Therapy in the Treatment of Diabetic Peripheral Neuropathy: A Protocol for Systematic Review and Meta-analysis of Randomized Controlled Trials

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2022 Apr 22

PMID 35451409

Authors

Longsheng Ren

Ruiying Guo

Guojing Fu

Jie Zhang

Qiang Wang

Affiliations

Soon will be listed here.

Abstract

Background: The incidence of diabetic peripheral neuropathy (DPN) is increasing year by year. If patients cannot receive timely and effective treatment, DPN may lead to diabetic foot ulcers or even amputation. This risk factor has been widely concerned around the world. Massage, as a non-invasive physical therapy method, is gradually being applied in the adjuvant treatment of DPN. However, there is no systematic review of the adjuvant treatment of DPN by massage. Our study will explore the effectiveness and safety of massage applied in DPN.

Methods: Eight electronic databases (PubMed, Cochrane, Web of Science, Sinomed, Embase, China National Knowledge Infrastructure, WanFang Data, Chongqing VIP Information) will be searched by our computer on February 9, 2022. A randomized controlled trial (RCT) of adjuvant massage therapy for DPN was screened. Primary outcome measures: efficiency, nerve conduction velocity. Secondary outcome measures: pain, blood glucose, and incidence of adverse reactions. The quality of the study was evaluated by two researchers using the RCT bias risk assessment tool in the Cochrane review manual Handbook5.4, and meta-analysis was performed by RevMan5.4 software.

Results: RCTs will be used to evaluate the clinical efficacy of massage adjuvant therapy in DPN.

Conclusion: This study will provide evidence-based evidence for the safety and effectiveness of massage adjuvant therapy in DPN.

Protocol Registration Number: INPLASY202220025.

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References

Martin C, Albers J, Pop-Busui R . Neuropathy and related findings in the diabetes control and complications trial/epidemiology of diabetes interventions and complications study. Diabetes Care. 2013; 37(1):31-8. PMC: 3868000. DOI: 10.2337/dc13-2114. View

Selvarajah D, Kar D, Khunti K, Davies M, Scott A, Walker J . Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention. Lancet Diabetes Endocrinol. 2019; 7(12):938-948. DOI: 10.1016/S2213-8587(19)30081-6. View

Girach A, Julian T, Varrassi G, Paladini A, Vadalouka A, Zis P . Quality of Life in Painful Peripheral Neuropathies: A Systematic Review. Pain Res Manag. 2019; 2019:2091960. PMC: 6556282. DOI: 10.1155/2019/2091960. View

Khawandanah J . Double or hybrid diabetes: A systematic review on disease prevalence, characteristics and risk factors. Nutr Diabetes. 2019; 9(1):33. PMC: 6828774. DOI: 10.1038/s41387-019-0101-1. View

Shourabi P, Bagheri R, Ashtary-Larky D, Wong A, Motevalli M, Hedayati A . Effects of hydrotherapy with massage on serum nerve growth factor concentrations and balance in middle aged diabetic neuropathy patients. Complement Ther Clin Pract. 2020; 39:101141. DOI: 10.1016/j.ctcp.2020.101141. View

Gok Metin Z, Donmez A, Izgu N, Ozdemir L, Arslan I . Aromatherapy Massage for Neuropathic Pain and Quality of Life in Diabetic Patients. J Nurs Scholarsh. 2017; 49(4):379-388. DOI: 10.1111/jnu.12300. View

Chatchawan U, Jarasrungsichol K, Yamauchi J . Immediate Effects of Self-Thai Foot Massage on Skin Blood Flow, Skin Temperature, and Range of Motion of the Foot and Ankle in Type 2 Diabetic Patients. J Altern Complement Med. 2020; 26(6):491-500. DOI: 10.1089/acm.2019.0328. View

Jaiswal M, Divers J, Dabelea D, Isom S, Bell R, Martin C . Prevalence of and Risk Factors for Diabetic Peripheral Neuropathy in Youth With Type 1 and Type 2 Diabetes: SEARCH for Diabetes in Youth Study. Diabetes Care. 2017; 40(9):1226-1232. PMC: 5566278. DOI: 10.2337/dc17-0179. View

Rivaz M, Rahpeima M, Khademian Z, Dabbaghmanesh M . The effects of aromatherapy massage with lavender essential oil on neuropathic pain and quality of life in diabetic patients: A randomized clinical trial. Complement Ther Clin Pract. 2021; 44:101430. DOI: 10.1016/j.ctcp.2021.101430. View

10.

Stino A, Smith A . Peripheral neuropathy in prediabetes and the metabolic syndrome. J Diabetes Investig. 2017; 8(5):646-655. PMC: 5583955. DOI: 10.1111/jdi.12650. View

11.

Hsu W, Guo S, Chang C . Back massage intervention for improving health and sleep quality among intensive care unit patients. Nurs Crit Care. 2019; 24(5):313-319. DOI: 10.1111/nicc.12428. View

12.

Wang G, Cong D, Ju H, Sun J, Li C, Zhang Z . Community intervention study of viscera massage in overweight/obese type 2 diabetes high-risk population. Medicine (Baltimore). 2022; 100(48):e27932. PMC: 9191379. DOI: 10.1097/MD.0000000000027932. View

13.

Castro-Sanchez A, Moreno-Lorenzo C, Mataran-Penarrocha G, Feriche-Fernandez-Castanys B, Labraca N, Sanchez Joya M . [Efficacy of a massage and exercise programme on the ankle-brachial index and blood pressure in patients with diabetes mellitus type 2 and peripheral arterial disease: a randomized clinical trial]. Med Clin (Barc). 2009; 134(3):107-10. DOI: 10.1016/j.medcli.2009.07.018. View

14.

Ardeleanu V, Toma A, Pafili K, Papanas N, Motofei I, Diaconu C . Current Pharmacological Treatment of Painful Diabetic Neuropathy: A Narrative Review. Medicina (Kaunas). 2020; 56(1). PMC: 7022869. DOI: 10.3390/medicina56010025. View

15.

dermanovic Dobrota V, Hrabac P, Skegro D, Smiljanic R, Dobrota S, Prkacin I . The impact of neuropathic pain and other comorbidities on the quality of life in patients with diabetes. Health Qual Life Outcomes. 2014; 12:171. PMC: 4264315. DOI: 10.1186/s12955-014-0171-7. View

16.

Cakici N, Fakkel T, van Neck J, Verhagen A, Coert J . Systematic review of treatments for diabetic peripheral neuropathy. Diabet Med. 2016; 33(11):1466-1476. DOI: 10.1111/dme.13083. View

17.

Iqbal Z, Azmi S, Yadav R, Ferdousi M, Kumar M, Cuthbertson D . Diabetic Peripheral Neuropathy: Epidemiology, Diagnosis, and Pharmacotherapy. Clin Ther. 2018; 40(6):828-849. DOI: 10.1016/j.clinthera.2018.04.001. View

18.

. Diabetic neuropathy. Nat Rev Dis Primers. 2019; 5(1):42. PMC: 7096070. DOI: 10.1038/s41572-019-0097-9. View

19.

Zis P, Sarrigiannis P, Rao D, Hewamadduma C, Hadjivassiliou M . Chronic idiopathic axonal polyneuropathy: a systematic review. J Neurol. 2016; 263(10):1903-10. DOI: 10.1007/s00415-016-8082-7. View

20.

Chatchawan U, Eungpinichpong W, Plandee P, Yamauchi J . Effects of thai foot massage on balance performance in diabetic patients with peripheral neuropathy: a randomized parallel-controlled trial. Med Sci Monit Basic Res. 2015; 21:68-75. PMC: 4416467. DOI: 10.12659/MSMBR.894163. View