Hybrid Peripheral Nerve Sheath Tumor of Parapharyngeal Space Having Features of Neurofibroma and Schwannoma in an 8-year-old Child - A Rare Entity

Overview

Journal J Oral Maxillofac Pathol

Date 2022 Apr 22

PMID 35450249

Authors

Himani Tiwari Chaturvedi

Chandrashekher Chaturvedi

Dipayan Jayanta Nandy

Affiliations

Soon will be listed here.

Abstract

Tumors of the parapharyngeal space (PPS) are extremely rare inpediatric age group. Out of all head-and-neck neoplasms, PPS tumors comprise only 0.5%. Majority of neoplasms in poststyloid PPS are neurogenic tumors. Conventional benign peripheral nerve sheath tumor (PNST) includes neurofibromas, schwannomas and perineuriomas. Hybrid PNSTs are rare entities having combined features of more than one histologic type, and the World Health Organization Classification of Tumors of the Central Nervous System, in the latest 2016, 4 edition, has recently recognized and published it. The most common hybrid tumor is schwannoma/perineuroma followed by neurofibroma/schwannoma and neurofibroma/perineuroma. Here, we are reporting a hybrid PNST which was completely excised and having combined features of neurofibroma and schwannoma, confirmed by both histopathologically and immunohistochemically, in an 8-year-old child, in PPS.

Citing Articles

Hybrid peripheral nerve sheath tumours - A Review.

Chaturvedi H, Chaturvedi C J Oral Maxillofac Pathol. 2025; 28(4):651-656.

PMID: 39949689 PMC: 11819630. DOI: 10.4103/jomfp.jomfp_126_24.

Solitary Hybrid Neurofibroma-Schwannoma of the Brachial Plexus in a 4-Year-Old Child.

Maddileti V J Indian Assoc Pediatr Surg. 2024; 29(5):566-568.

PMID: 39479417 PMC: 11521212. DOI: 10.4103/jiaps.jiaps_75_24.

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