Sirenomelia: A Case Report

Overview

Journal SAGE Open Med Case Rep

Publisher Sage Publications

Specialty General Medicine

Date 2022 Apr 22

PMID 35449530

Authors

Ayanaw Tamene

Mandefro Molla

Affiliations

Soon will be listed here.

Abstract

Sirenomelia also known as mermaid syndrome is a partial or complete fusion of lower extremities associated with visceral anomalies. It is a rare anomaly with a poor prognosis. Maternal age less than 20 years, maternal diabetes mellitus, and monozygotic twinning are some of the known risk factors. Diagnosis can be made via antenatal ultrasound or typical physical appearance after birth. A 2200 g baby was born from 18-year-old non-consanguineous mother via assisted breech delivery. The baby had fused lower limbs with 10 toes, absent external genitalia, and a single umbilical artery. It was small for gestational age. The baby was passed away after 30 min of birth. Young maternal age (18 years) was the identified risk factor for sirenomelia in this case. We recommend an early routine ultrasound anomaly scan in all pregnant women particularly for early detection and termination of pregnancy as the prognosis is poor. Avoiding teenager pregnancy and strict control of blood sugar in diabetic mothers can decrease this anomaly.

Citing Articles

Mermaid Syndrome: Navigating the Challenges of a Rare Congenital Disorder.

Tanveer S, Abbas A, Obando Cabezas M, Tahir H, Thampi T Cureus. 2024; 16(10):e71317.

PMID: 39534800 PMC: 11554444. DOI: 10.7759/cureus.71317.

References

Turgut H, Ozdemir R, Gokce I, Karakurt C, Karadag A . Sirenomelia associated with Hypoplastic Left Heart in a Newborn. Balkan J Med Genet. 2017; 20(1):91-94. PMC: 5596827. DOI: 10.1515/bjmg-2017-0001. View

Kucuk S, Kucuk I . Sirenomelia (Mermaid Syndrome): A Case Report. Turk Patoloji Derg. 2020; 36(3):256-260. PMC: 10510598. DOI: 10.5146/tjpath.2020.01491. View

Sikandar R, Munim S . Sirenomelia, the Mermaid syndrome: case report and a brief review of literature. J Pak Med Assoc. 2009; 59(10):721-3. View

Ramphul K, Mejias S, Ramphul-Sicharam Y . Mermaid Syndrome: A Case Report in Mauritius. Cureus. 2018; 10(2):e2210. PMC: 5910014. DOI: 10.7759/cureus.2210. View

Shojaee A, Ronnasian F, Behnam M, Salehi M . Sirenomelia: two case reports. J Med Case Rep. 2021; 15(1):217. PMC: 8077960. DOI: 10.1186/s13256-021-02699-4. View

Al Hadhoud F, Kamal A, Al Anjari A, Diejomaoh M . Fusion of lower limbs with severe urogenital malformation in a newborn, a rare congenital clinical syndrome: case report. Int Med Case Rep J. 2017; 10:313-317. PMC: 5614763. DOI: 10.2147/IMCRJ.S139067. View

Georgiades C . Etymology of selected medical terms used in radiology: the mythologic connection. AJR Am J Roentgenol. 2002; 178(5):1101-7. DOI: 10.2214/ajr.178.5.1781101. View

Orioli I, Amar E, Arteaga-Vazquez J, Bakker M, Bianca S, Botto L . Sirenomelia: an epidemiologic study in a large dataset from the International Clearinghouse of Birth Defects Surveillance and Research, and literature review. Am J Med Genet C Semin Med Genet. 2011; 157C(4):358-73. PMC: 4492125. DOI: 10.1002/ajmg.c.30324. View

Tilahun T, Desta D . Successful Expectant Management of the Anomalous Fetus with Sirenomelia in Twin Pregnancy: A Case Report and Literature Review. Int Med Case Rep J. 2021; 14:229-232. PMC: 8043792. DOI: 10.2147/IMCRJ.S300318. View

10.

Twickler D, Budorick N, Pretorius D, Grafe M, Currarino G . Caudal regression versus sirenomelia: sonographic clues. J Ultrasound Med. 1993; 12(6):323-30. DOI: 10.7863/jum.1993.12.6.323. View

11.

Tonni G, Gabriele T, Grisolia G, Gianpaolo G . Sirenomelia: a review on embryogenic enviromental theories, novel three-dimensional ultrasound imaging and first trimester diagnosis in a case of mosaic 69,XXX/46,XX fetus. Arch Gynecol Obstet. 2013; 288(1):3-11. DOI: 10.1007/s00404-013-2847-3. View

12.

Kulkarni M, Sureshkumar C, Sindhur P . Sirenomelia with spina bifida. Indian Pediatr. 1994; 31(1):51-5. View

13.

Kavunga E, Bunduki G, Mumbere M, Masumbuko C . Sirenomelia associated with an anterior abdominal wall defect: a case report. J Med Case Rep. 2019; 13(1):213. PMC: 6626367. DOI: 10.1186/s13256-019-2162-0. View

14.

Das B, Rajegowda B, Bainbridge R, Giampietro P . Caudal regression syndrome versus sirenomelia: a case report. J Perinatol. 2002; 22(2):168-70. DOI: 10.1038/sj.jp.7210598. View

15.

Stocker J, Heifetz S . Sirenomelia. A morphological study of 33 cases and review of the literature. Perspect Pediatr Pathol. 1987; 10:7-50. View

16.

Morales-Rosello J, Loscalzo G, Buongiorno S, Jakaite V, Perales-Marin A . Sirenomelia, case report and review of the literature. J Matern Fetal Neonatal Med. 2020; 35(6):1203-1206. DOI: 10.1080/14767058.2020.1742693. View

17.

Morfaw F, Nana P . Sirenomelia in a Cameroonian woman: a case report and review of the literature. F1000Res. 2014; 1:6. PMC: 3917649. DOI: 10.12688/f1000research.1-6.v2. View

18.

Ugwu R, Eneh A, Wonodi W . Sirenomelia in a Nigerian triplet: a case report. J Med Case Rep. 2011; 5:426. PMC: 3179757. DOI: 10.1186/1752-1947-5-426. View