Simultaneous or Staged Resection for Synchronous Liver Metastasis and Primary Rectal Cancer: a Propensity Score Matching Analysis

Overview

Journal BMC Gastroenterol

Publisher Biomed Central

Specialty Gastroenterology

Date 2022 Apr 22

PMID 35448953

Authors

Elias Karam

Petru Bucur

Camille Gil

Remy Sindayigaya

Nicolas Tabchouri

Louise Barbier

Urs Pabst-Giger

Pascal Bourlier

Thierry Lecomte

Driffa Moussata

Sophie Chapet

Gilles Calais

Mehdi Ouaissi

Ephrem Salame

Affiliations

Soon will be listed here.

Abstract

Background: Colorectal cancer is the third most common cancer in France and by the time of the diagnosis, 15-25% of patients will suffer from synchronous liver metastases. Surgery associated to neoadjuvant treatment can cure these patients, but few studies focus only on rectal cancer. This study was meant to compare the outcomes of patients who underwent a simultaneous resection to those who underwent a staged resection (rectum first or liver first) in the University Hospital of Tours, France.

Methods: We assessed retrospectively a prospective maintained data base about the clinical, pathological and survival outcomes of patients who underwent a simultaneous or a staged resection in our center between 2010 and 2018. A propensity score matching was used, considering the initial characteristics of our groups.

Results: There were 70 patients (55/15 males, female respectively) with median age 60 (54-68) years. After matching 48 (69%) of them underwent a staged approach and 22 (31%) a simultaneous approach were compared. After PSM, there were 22 patients in each group. No differences were found in terms of morbidity (p = 0.210), overall survival (p = 0.517) and disease-free survival (p = 0.691) at 3 years after matching. There were significantly less recurrences in the simultaneous group (50% vs 81.8%, p = 0.026).

Conclusions: Simultaneous resection of the rectal primary cancer and synchronous liver metastases is safe and feasible with no difference in terms of survival.

Citing Articles

Safety and long-term prognosis of simultaneous versus staged resection in synchronous colorectal cancer with liver metastasis: a systematic review and meta-analysis.

Wang S, Song L, Tang J, Sun W, Li Z Eur J Med Res. 2022; 27(1):297.

PMID: 36529740 PMC: 9762091. DOI: 10.1186/s40001-022-00937-z.

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