Immune Responses in Leishmaniasis: An Overview

Overview

Journal Trop Med Infect Dis

Specialty Infectious Diseases

Date 2022 Apr 21

PMID 35448829

Authors

Ana Caroline Costa-da-Silva

Danielle de Oliveira Nascimento

Jesuino R M Ferreira

Kamila Guimaraes-Pinto

Leonardo Freire-de-Lima

Alexandre Morrot

Debora Decote-Ricardo

Alessandra Almeida Filardy

Celio Geraldo Freire-de-Lima

Affiliations

Soon will be listed here.

Abstract

Leishmaniasis is a parasitic, widespread, and neglected disease that affects more than 90 countries in the world. More than 20 species cause different forms of leishmaniasis that range in severity from cutaneous lesions to systemic infection. The diversity of leishmaniasis forms is due to the species of parasite, vector, environmental and social factors, genetic background, nutritional status, as well as immunocompetence of the host. Here, we discuss the role of the immune system, its molecules, and responses in the establishment, development, and outcome of Leishmaniasis, focusing on innate immune cells and interactions.

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