FKBP39 Controls the Larval Stage JH Activity and Development in

Overview

Journal Insects

Specialty Biology

Date 2022 Apr 21

PMID 35447772

Authors

Xinyu Wang

Ying Zhou

Jianwen Guan

Yang Cheng

Yingying Lu

Youheng Wei

Affiliations

Soon will be listed here.

Abstract

FK506-binding protein 39kD (FKBP39) localizes in the nucleus and contains multiple functional domains. Structural analysis suggests that FKBP39 might function as a transcriptional factor and control juvenile hormone (JH) activity. Here, we show that FKBP39 expresses at a high level and localizes in the nucleolus of fat body cells during the first two larval stages and early third larval stage. The mutant displays delayed larval-pupal transition and an increased expression of , the main mediator of the JH pathway, at the early third larval stage. Moreover, the mutant has a fertility defect that is independent of JH activity. Interestingly, the expression of , the most widely used reference gene for qRT-PCR in Drosophila, significantly decreased in the mutant, suggesting that FKBP39 might regulate ribosome assembly. Taken together, our data demonstrate the expression pattern and physiological roles of FKBP39 in Drosophila.

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