The FAR Protein Family of Parasitic Nematodes

Overview

Journal PLoS Pathog

Specialty Microbiology

Date 2022 Apr 21

PMID 35446920

Authors

Sophia C Parks

Susan Nguyen

Martin J Boulanger

Adler R Dillman

Affiliations

Soon will be listed here.

Abstract

Fatty acid-and retinol-binding proteins (FARs) belong to a unique family of excreted/secreted proteins (ESPs) found exclusively in nematodes. Much of our understanding of these proteins, however, is limited to their in vitro binding characteristics toward various fatty acids and retinol and has provided little insight into their in vivo functions or mechanisms. Recent research, however, has shown that FARs elicit an immunomodulatory role in plant and animal model systems, likely by sequestering lipids involved in immune signaling. This alludes to the intricate relationship between parasitic nematode effectors and their hosts.

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