Macrocytic Anaemia: Not Always a Straightforward Diagnosis
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Abstract
Macrocytosis is defined as a mean corpuscular volume greater than 100 femtolitres (fL). There are several causes for macrocytic anaemia, and they can be divided into megaloblastic or non-megaloblastic anaemia. Vitamin B12 deficiency is one of the most common causes of megaloblastic anaemia. The cause of vitamin B12 deficiency must be evaluated including the presence of pernicious anaemia as it could alter the treatment and follow-up. Pernicious anaemia can be associated with other autoimmune diseases constituting polyglandular syndromes.
References
1.
Menke D, Hook C
. A practical approach to the differential diagnosis and evaluation of the adult patient with macrocytic anemia. Med Clin North Am. 1992; 76(3):581-97.
DOI: 10.1016/s0025-7125(16)30341-8.
View
2.
Savage D, Ogundipe A, Allen R, Stabler S, Lindenbaum J
. Etiology and diagnostic evaluation of macrocytosis. Am J Med Sci. 2000; 319(6):343-52.
DOI: 10.1097/00000441-200006000-00001.
View
3.
Phillips J, Henderson A
. Hemolytic Anemia: Evaluation and Differential Diagnosis. Am Fam Physician. 2018; 98(6):354-361.
View
4.
Noel N, Maigne G, Tertian G, Anguel N, Monnet X, Michot J
. Hemolysis and schistocytosis in the emergency department: consider pseudothrombotic microangiopathy related to vitamin B12 deficiency. QJM. 2013; 106(11):1017-22.
DOI: 10.1093/qjmed/hct142.
View
5.
Norasyikin A, Rozita M, Mohd Johan M, Suehazlyn Z
. Autoimmune polyglandular syndrome presenting with jaundice and thrombocytopenia. Med Princ Pract. 2014; 23(4):387-9.
PMC: 5586888.
DOI: 10.1159/000357645.
View