Serum Adiponectin and Cortisol Levels Are Not Affected by Studied ADIPOQ Gene Variants: Tehran Lipid and Glucose Study

Overview

Journal BMC Endocr Disord

Publisher Biomed Central

Specialty Endocrinology

Date 2022 Apr 19

PMID 35436947

Authors

Masoumeh Nezhadali

Seyed Alireza Mesbah-Namin

Mehdi Hedayati

Mahdi Akbarzadeh

Leila Najd Hassan Bonab

Maryam S Daneshpour

Affiliations

Soon will be listed here.

Abstract

Background: Obesity is a major public health concern in developed and even developing countries worldwide. Adiponectin is a protein secreted by adipose tissue that modulates many metabolic processes and plays a vital role in obesity. This study aimed to determine the association of four variants of the ADIPOQ gene with serum adiponectin, cortisol levels and obesity status.

Methods: This case-control study was performed on 164 obese individuals compared by 156 control from the Tehran Lipid and Glucose Study (TLGS). Standard procedures obtained anthropometric measures and metabolic parameters. Cortisol and adiponectin levels were measured by ELISA method. rs1501299, rs266729, rs17300539, and rs17366743 on the ADIPOQ gene were genotyped using the PCR-RFLP. The correlation between adiponectin gene SNPs and obesity were calculated by Additive, dominant, and recessive genetic models. Pearson's or Spearman's found correlations between adiponectin levels and metabolic and anthropometric variables. Data were analyzed using SPSS software Version 20.

Results: Adiponectin and cortisol levels were significantly lower in obese subjects compared to the control group (p < 0.05). There was a significant negative correlation between serum adiponectin level and BMI, waist circumference (WC), waist-hip ratio, hip circumference (HC), Fasting blood sugar (FBS) Triglyceride (TG), Total cholesterol (TC), Systolic blood pressure (SBP), Diastolic blood pressure (DBP) (r = - 0.147, r = - 0.324, r = 0.371, r = - 0.179, r = - 0.299, r = - 0.277, r = - 0.041, r = - 0.134, and r = - 0.149, respectively). A positive correlation was found between adiponectin and high-density lipoprotein cholesterol (HDL-C) (r = 0.29), but no significant correlations were found between adiponectin and Low-density lipoprotein cholesterol(LDL-C) and cortisol. ADIPOQ variant rs1501299 was significantly associated with cortisol levels in subjects with BMI ≥ 25 (P-value =0.039).

Conclusions: Adiponectin and cortisol levels were associated with obesity. No ADIPOQ gene variants and haplotypes were associated with cortisol, Adiponectin, and obesity.

Citing Articles

Secondary Transcriptomic Analysis of Triple-Negative Breast Cancer Reveals Reliable Universal and Subtype-Specific Mechanistic Markers.

Rapier-Sharman N, Spendlove M, Poulsen J, Appel A, Wiscovitch-Russo R, Vashee S Cancers (Basel). 2024; 16(19).

PMID: 39409999 PMC: 11476281. DOI: 10.3390/cancers16193379.

Comparison of Adiponectin Levels in Anorexia Nervosa, Bulimia Nervosa, Binge-Eating Disorder, Obesity, Constitutional Thinness, and Healthy Controls: A Network Meta-Analysis.

Tural U, Sparpana A, Sullivan E, Iosifescu D Life (Basel). 2023; 13(5).

PMID: 37240826 PMC: 10220738. DOI: 10.3390/life13051181.

Effect of Genetic Variations in the Gene on Susceptibility to Type 2 Diabetes Mellitus.

Al-Nbaheen M Diabetes Metab Syndr Obes. 2022; 15:2753-2761.

PMID: 36101664 PMC: 9464438. DOI: 10.2147/DMSO.S377057.

References

Ricci R, Bevilacqua F . The potential role of leptin and adiponectin in obesity: a comparative review. Vet J. 2011; 191(3):292-8. DOI: 10.1016/j.tvjl.2011.04.009. View

Nascimento H, Vieira E, Coimbra S, Catarino C, Costa E, Bronze-da-Rocha E . Adipokine Gene Single-Nucleotide Polymorphisms in Portuguese Obese Adolescents: Associations with Plasma Concentrations of Adiponectin, Resistin, IL-6, IL-1β, and TNF-α. Child Obes. 2016; 12(4):300-13. DOI: 10.1089/chi.2015.0235. View

Shirazi F, Khodamoradi Z, Jeddi M . Insulin resistance and high molecular weight adiponectin in obese and non-obese patients with Polycystic Ovarian Syndrome (PCOS). BMC Endocr Disord. 2021; 21(1):45. PMC: 7941970. DOI: 10.1186/s12902-021-00710-z. View

Ronconi V, Turchi F, Rilli S, Di Mattia D, Agostinelli L, Boscaro M . Metabolic syndrome in primary aldosteronism and essential hypertension: relationship to adiponectin gene variants. Nutr Metab Cardiovasc Dis. 2009; 20(2):93-100. DOI: 10.1016/j.numecd.2009.03.007. View

Hivert M, Manning A, McAteer J, Florez J, Dupuis J, Fox C . Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study. Diabetes. 2008; 57(12):3353-9. PMC: 2584143. DOI: 10.2337/db08-0700. View

Cui M, Gao Y, Zhao Y, Pang H, Chen L, Wang Z . Association between Adiponectin Gene Polymorphism and Environmental Risk Factors of Type 2 Diabetes Mellitus among the Chinese Population in Hohhot. Biomed Res Int. 2020; 2020:6383906. PMC: 7327607. DOI: 10.1155/2020/6383906. View

Corbi G, Polito R, Monaco M, Cacciatore F, Scioli M, Ferrara N . Adiponectin Expression and Genotypes in Italian People with Severe Obesity Undergone a Hypocaloric Diet and Physical Exercise Program. Nutrients. 2019; 11(9). PMC: 6769478. DOI: 10.3390/nu11092195. View

Sull J, Kim H, Yun J, Kim G, Park E, Kim S . Serum adiponectin is associated with family history of diabetes independently of obesity and insulin resistance in healthy Korean men and women. Eur J Endocrinol. 2008; 160(1):39-43. DOI: 10.1530/EJE-08-0603. View

Goto A, Noda M, Goto M, Yasuda K, Mizoue T, Yamaji T . Plasma adiponectin levels, ADIPOQ variants, and incidence of type 2 diabetes: A nested case-control study. Diabetes Res Clin Pract. 2017; 127:254-264. DOI: 10.1016/j.diabres.2017.03.020. View

10.

Ruttle P, Javaras K, Klein M, Armstrong J, Burk L, Essex M . Concurrent and longitudinal associations between diurnal cortisol and body mass index across adolescence. J Adolesc Health. 2013; 52(6):731-7. PMC: 3654073. DOI: 10.1016/j.jadohealth.2012.11.013. View

11.

Mota-Zamorano S, Luna E, Garcia-Pino G, Gonzalez L, Gervasini G . Combined donor-recipient genotypes of leptin receptor and adiponectin gene polymorphisms affect the incidence of complications after renal transplantation. Mol Genet Metab Rep. 2020; 25:100648. PMC: 7498839. DOI: 10.1016/j.ymgmr.2020.100648. View

12.

Petrone A, Zavarella S, Caiazzo A, Leto G, Spoletini M, Potenziani S . The promoter region of the adiponectin gene is a determinant in modulating insulin sensitivity in childhood obesity. Obesity (Silver Spring). 2006; 14(9):1498-504. DOI: 10.1038/oby.2006.172. View

13.

Gu H . Biomarkers of adiponectin: plasma protein variation and genomic DNA polymorphisms. Biomark Insights. 2009; 4:123-33. PMC: 2796863. DOI: 10.4137/bmi.s3453. View

14.

Song J, Yoon S, Kim O . T allele at rs1501299 G/T polymorphism is more susceptible to the influence of circulating adiponectin on arterial stiffness in nondiabetic men. Diabetol Metab Syndr. 2018; 10:44. PMC: 5987468. DOI: 10.1186/s13098-018-0345-2. View

15.

Gariballa S, Alkaabi J, Yasin J, Al Essa A . Total adiponectin in overweight and obese subjects and its response to visceral fat loss. BMC Endocr Disord. 2019; 19(1):55. PMC: 6545728. DOI: 10.1186/s12902-019-0386-z. View

16.

Hornsby W, Haff G, Suarez D, Ramsey M, Triplett N, Hardee J . Alterations in Adiponectin, Leptin, Resistin, Testosterone, and Cortisol across Eleven Weeks of Training among Division One Collegiate Throwers: A Preliminary Study. J Funct Morphol Kinesiol. 2021; 5(2). PMC: 7739239. DOI: 10.3390/jfmk5020044. View

17.

Karimi H, Nezhadali M, Hedayati M . Association between adiponectin rs17300539 and rs266729 gene polymorphisms with serum adiponectin level in an Iranian diabetic/pre-diabetic population. Endocr Regul. 2019; 52(4):176-184. DOI: 10.2478/enr-2018-0022. View

18.

Breitfeld J, Stumvoll M, Kovacs P . Genetics of adiponectin. Biochimie. 2012; 94(10):2157-63. DOI: 10.1016/j.biochi.2012.03.004. View

19.

Imamura H, Nagayama D, Ishihara N, Tanaka S, Watanabe R, Watanabe Y . Resveratrol attenuates triglyceride accumulation associated with upregulation of Sirt1 and lipoprotein lipase in 3T3-L1 adipocytes. Mol Genet Metab Rep. 2017; 12:44-50. PMC: 5448575. DOI: 10.1016/j.ymgmr.2017.05.003. View

20.

Kiecolt-Glaser J, Christian L, Andridge R, Hwang B, Malarkey W, Belury M . Adiponectin, leptin, and yoga practice. Physiol Behav. 2012; 107(5):809-13. PMC: 3350834. DOI: 10.1016/j.physbeh.2012.01.016. View