Non-tolerance and Autoantibodies to a Transgenic Self Antigen Expressed in Pancreatic Beta Cells

Overview

Journal Nature

Specialty Science

Date 1987 Jan 15

PMID 3543686

Citations 55

Authors

T E Adams

S Alpert

D Hanahan

Affiliations

Soon will be listed here.

Abstract

Transgenic mice expressing simian virus 40 T antigen under control of the insulin gene regulatory region vary in their response to this protein. Each lineage is characteristically either tolerant to T antigen, or not, in which case autoantibodies arise with high frequency, and lymphocytes infiltrate and disrupt the pancreatic islets. Both non-tolerance and the autoimmune response appear to result from delayed onset of T antigen expression during beta cell development.

Citing Articles

Models in Pancreatic Neuroendocrine Neoplasms: Current Perspectives and Future Directions.

Forsythe S, Pu T, Andrews S, Madigan J, Sadowski S Cancers (Basel). 2023; 15(15).

PMID: 37568572 PMC: 10416968. DOI: 10.3390/cancers15153756.

Obesity and cancer-extracellular matrix, angiogenesis, and adrenergic signaling as unusual suspects linking the two diseases.

Pellegata N, Diaz M, Rohm M, Herzig S Cancer Metastasis Rev. 2022; 41(3):517-547.

PMID: 36074318 PMC: 9470659. DOI: 10.1007/s10555-022-10058-y.

High endothelial venules (HEVs) in immunity, inflammation and cancer.

Blanchard L, Girard J Angiogenesis. 2021; 24(4):719-753.

PMID: 33956259 PMC: 8487881. DOI: 10.1007/s10456-021-09792-8.

A phenotype from tumor stroma based on the expression of metalloproteases and their inhibitors, associated with prognosis in breast cancer.

Eiro N, Fernandez-Garcia B, Vazquez J, del Casar J, Gonzalez L, Vizoso F Oncoimmunology. 2015; 4(7):e992222.

PMID: 26140253 PMC: 4485729. DOI: 10.4161/2162402X.2014.992222.

Tumor angiogenesis in the absence of fibronectin or its cognate integrin receptors.

Murphy P, Begum S, Hynes R PLoS One. 2015; 10(3):e0120872.

PMID: 25807551 PMC: 4373772. DOI: 10.1371/journal.pone.0120872.