Improvement of Cytotoxicity and Necrosis Activity of Ganoderic Acid a Through the Development of PMBN-A.Her2-GA As a Targeted Nano System

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 Apr 15

PMID 35425091

Authors

P Motamed Fath

M Rahimnejad

S Moradi-Kalbolandi

B Ebrahimi Hosseinzadeh

T Jamshidnejad-Tosaramandani

Affiliations

Soon will be listed here.

Abstract

The targeting nano carriers have been promptly proposed to overcome the current obstacles in conventional chemotherapy approaches for cancer. Currently, PMBN (poly[MPC--(BMA)--(MEONP)]), is considered as a promising amphiphilic polymer that could be easily targeted and conjugated to hydrophobic substances with low bioavailability. To target breast cancer cells overexpressing human epidermal receptor 2 (HER2) receptors, anti-HER2 monoclonal antibody (A.Her2) was conjugated to PMBN and afterward loaded with ganoderic acid A (GA-A) as an anti-cancer metabolite. The efficacy of conjugation and loading was reasonably favourable. The rod shape of the polymer with a size of approximately 160 ± 30 nm was confirmed. Our results indicated that PMBN-A.Her2-GA is an anionic nanostructure with an appropriate form and capable of being applied in cancer therapy. Subsequently, cytotoxicity analysis revealed an improved anti-proliferative effect of GA-A.

Citing Articles

Research Progress on the Biological Activity of Ganoderic Acids in over the Last Five Years.

Wang S, Wang L, Shangguan J, Jiang A, Ren A Life (Basel). 2024; 14(10).

PMID: 39459639 PMC: 11509451. DOI: 10.3390/life14101339.

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