Inorganic Process for Wet Silica-doping of Calcium Phosphate

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 Apr 15

PMID 35423780

Authors

Yuki Sugiura

Kodai Niitsu

Yasuko Saito

Takashi Endo

Masanori Horie

Affiliations

Soon will be listed here.

Abstract

Silica is not only a biocompatible trace element but also an essential element for bone formation and metabolism. Therefore, it is often doped into bioceramics such as calcium phosphate and calcium carbonate for enhancing biomaterial ability. Heretofore, organic silica materials are employed as silica sources, but the residual organic matter is a significant drawback in biomaterial applications. Therefore, in this study, we introduce a one-pot inorganic synthesis method for the formation of silica-doped octacalcium phosphate (OCP) using NaSiO as the silica source. Silica was intercalated into the OCP unit lattice, replacing its hydrous layer structure, and then a layer-by-layer structure of apatite and silica was formed. Furthermore, by immersing the fabricated silica-doped OCP into suitable solutions, both silica-doped hydroxyapatite and carbonate apatite were fabricated through a one-step inorganic processes.

Citing Articles

Superior bone regenerative properties of carbonate apatite with locational bone-active factors through an inorganic process.

Sugiura Y, Ono F, Nohara M, Funabiki M, Kutara K, Kanda T Regen Ther. 2024; 26:760-766.

PMID: 39309398 PMC: 11414537. DOI: 10.1016/j.reth.2024.08.021.

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