A Conserved Module Regulates Receptor Kinase Signalling in Immunity and Development

Overview

Journal Nat Plants

Specialties Biology
Genetics

Date 2022 Apr 15

PMID 35422079

Authors

Thomas A DeFalco

Pauline Anne

Sean R James

Andrew C Willoughby

Florian Schwanke

Oliver Johanndrees

Yasmine Genolet

Paul Derbyshire

Qian Wang

Surbhi Rana

Anne-Marie Pullen

Frank L H Menke

Cyril Zipfel

Christian S Hardtke

Zachary L Nimchuk

Affiliations

Soon will be listed here.

Abstract

Ligand recognition by cell-surface receptors underlies development and immunity in both animals and plants. Modulating receptor signalling is critical for appropriate cellular responses but the mechanisms ensuring this are poorly understood. Here, we show that signalling by plant receptors for pathogen-associated molecular patterns (PAMPs) in immunity and CLAVATA3/EMBRYO SURROUNDING REGION-RELATED peptides (CLEp) in development uses a similar regulatory module. In the absence of ligand, signalling is dampened through association with specific type-2C protein phosphatases. Upon activation, PAMP and CLEp receptors phosphorylate divergent cytosolic kinases, which, in turn, phosphorylate the phosphatases, thereby promoting receptor signalling. Our work reveals a regulatory circuit shared between immune and developmental receptor signalling, which may have broader important implications for plant receptor kinase-mediated signalling in general.

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