CTCF Puts a New Twist on UV Damage and Repair in Skin Cancer

Overview

Journal Mol Cell Oncol

Specialty Oncology

Date 2022 Apr 14

PMID 35419468

Authors

Bastian Stark

Gregory M K Poon

John J Wyrick

Affiliations

Soon will be listed here.

Abstract

Somatic mutations in skin cancers are highly enriched at binding sites for CCCTC-binding factor (CTCF). We have discovered that CTCF binding alters the DNA structure to render it more susceptible to UV damage. Elevated UV damage formation at CTCF binding sites, in conjunction with subsequent repair inhibition, promotes UV mutagenesis.

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