First-in-clinical Application of a Time-gated Diffuse Correlation Spectroscopy System at 1064 nm Using Superconducting Nanowire Single Photon Detectors in a Neuro Intensive Care Unit

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2022 Apr 13

PMID 35414986

Authors

Chien-Sing Poon

Dharminder S Langri

Benjamin Rinehart

Timothy M Rambo

Aaron J Miller

Brandon Foreman

Ulas Sunar

Affiliations

Soon will be listed here.

Abstract

Recently proposed time-gated diffuse correlation spectroscopy (TG-DCS) has significant advantages compared to conventional continuous wave (CW)-DCS, but it is still in an early stage and clinical capability has yet to be established. The main challenge for TG-DCS is the lower signal-to-noise ratio (SNR) when gating for the deeper traveling late photons. Longer wavelengths, such as 1064 nm have a smaller effective attenuation coefficient and a higher power threshold in humans, which significantly increases the SNR. Here, we demonstrate the clinical utility of TG-DCS at 1064 nm in a case study on a patient with severe traumatic brain injury admitted to the neuro-intensive care unit (neuroICU). We showed a significant correlation between TG-DCS early (ρ = 0.67) and late (ρ = 0.76) gated against invasive thermal diffusion flowmetry. We also analyzed TG-DCS at high temporal resolution (50 Hz) to elucidate pulsatile flow data. Overall, this study demonstrates the first clinical translation capability of the TG-DCS system at 1064 nm using a superconducting nanowire single-photon detector.

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