» Articles » PMID: 35411604

MiR-3184-3p Enriched in Cerebrospinal Fluid Exosomes Contributes to Progression of Glioma and Promotes M2-like Macrophage Polarization

Overview
Journal Cancer Sci
Specialty Oncology
Date 2022 Apr 12
PMID 35411604
Authors
Affiliations
Soon will be listed here.
Abstract

Liquid biopsy is a novel strategy for tumour diagnosis. The contents of cerebrospinal fluid (CSF) exosomes could reflect glioma status, hence sampling exosomes from CSF is a means of liquid biopsy for glioma. However, few studies have focused on the function of microRNAs in CSF exosomes. In this study, we found that miR-3184-3p was enriched in CSF exosomes in glioma patients and was downregulated after tumour resection. We found that miR-3184 facilitates glioma progression in two ways. On the one hand, miR-3184 directly promotes proliferation, migration, and invasion while inhibiting apoptosis in glioma. On the other hand, miR-3184 in glioma-derived exosomes polarizes macrophages to an M2-like phenotype, which further aggravates tumour progression. Overall, the current findings uncovered a new mechanism and highlighted the significant role of miR-3184 in glioma progression. Furthermore, exosomal miR-3184 could be a considerable factor with potential applications in glioma diagnosis and treatment in the future.

Citing Articles

Exploring the roles and clinical potential of exosome-derived non-coding RNAs in glioma.

Jin P, Bai X IBRO Neurosci Rep. 2025; 18:323-337.

PMID: 40034544 PMC: 11872630. DOI: 10.1016/j.ibneur.2025.01.015.


Exosomes of stem cells: a potential frontier in the treatment of osteoarthritis.

Wang X, Xu L, Wu Z, Lou L, Xia C, Miao H Precis Clin Med. 2025; 8(1):pbae032.

PMID: 39781279 PMC: 11705996. DOI: 10.1093/pcmedi/pbae032.


Mechanism of cold exposure delaying wound healing in mice.

Li F, Liu J, Lei L, Li Y, Xu F, Lin X J Nanobiotechnology. 2024; 22(1):723.

PMID: 39568002 PMC: 11577949. DOI: 10.1186/s12951-024-03009-y.


The negative effects of extracellular vesicles in the immune system.

Wang Y, Li C, Wu F, Mao J, Zhu J, Xie H Front Immunol. 2024; 15:1410273.

PMID: 39372421 PMC: 11449741. DOI: 10.3389/fimmu.2024.1410273.


The role and application of small extracellular vesicles in glioma.

Yang Z, Wu H, Wang Z, Bian E, Zhao B Cancer Cell Int. 2024; 24(1):229.

PMID: 38951882 PMC: 11218314. DOI: 10.1186/s12935-024-03389-z.


References
1.
Xu S, Zhang J, Xue H, Han X, Li T, Guo X . MicroRNA-584-3p reduces the vasculogenic mimicry of human glioma cells by regulating hypoxia-induced ROCK1 dependent stress fiber formation. Neoplasma. 2016; 64(1):13-21. DOI: 10.4149/neo_2017_102. View

2.
Jafari D, Tiyuri A, Rezaei E, Moradi Y, Jafari R, Jokar Shoorijeh F . Diagnostic accuracy of cerebrospinal fluid and serum-isolated extracellular vesicles for glioblastoma: a systematic review and meta-analysis. Expert Rev Mol Diagn. 2020; 20(11):1075-1085. DOI: 10.1080/14737159.2020.1844006. View

3.
Li H, Jiang T, Li M, Zheng X, Zhao G . Transcriptional Regulation of Macrophages Polarization by MicroRNAs. Front Immunol. 2018; 9:1175. PMC: 5985397. DOI: 10.3389/fimmu.2018.01175. View

4.
Bang C, Batkai S, Dangwal S, Gupta S, Foinquinos A, Holzmann A . Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy. J Clin Invest. 2014; 124(5):2136-46. PMC: 4001534. DOI: 10.1172/JCI70577. View

5.
Jones J, Nguyen H, Drummond K, Morokoff A . Circulating Biomarkers for Glioma: A Review. Neurosurgery. 2021; 88(3):E221-E230. DOI: 10.1093/neuros/nyaa540. View