Laminar Necrosis and Hypoxic Damage of the Placenta: A Case-Control Study

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2022 Apr 12

PMID 35409574

Authors

Katia Mangialardi

Margherita Fanelli

Gerardo Cazzato

Andrea Marzullo

Maria Elisabetta Baldassarre

Antonella Vimercati

Leonardo Resta

Affiliations

Soon will be listed here.

Abstract

The aim of this study is to verify the role of laminar necrosis (LN) in the diagnosis of hypoxic damage of the placenta. This is a retrospective case-control study in which 50 cases with laminar necrosis were compared with 100 gestational age-matched controls without laminar necrosis in a 1:2 ratio. The parameters analyzed were: the presence of other placental lesions, obstetric characteristics and neonatal outcome. For each of the 50 cases, the area affected by the lesion was detected, and the lesions were classified into three groups based on the morphology and time of onset of the lesion in order to understand whether these characteristics of the lesion had a clinical-pathology. The results showed that including the search for LN among placental lesions generally examined is useful to guide the pathologist in the diagnosis of placental dysfunction of hypoxic origin.

References

Shah G, Budhathoki S, Das B, Mandal R . Risk factors in early neonatal sepsis. Kathmandu Univ Med J (KUMJ). 2008; 4(2):187-91. View

Stanek J . Acute and chronic placental membrane hypoxic lesions. Virchows Arch. 2009; 455(4):315-22. DOI: 10.1007/s00428-009-0841-8. View

Stanek J . Diagnosing placental membrane hypoxic lesions increases the sensitivity of placental examination. Arch Pathol Lab Med. 2010; 134(7):989-95. DOI: 10.5858/2009-0280-OA.1. View

Hsu A, Guan M, Johannesen E, Stephens A, Khaleel N, Kagan N . Placental SARS-CoV-2 in a pregnant woman with mild COVID-19 disease. J Med Virol. 2020; 93(2):1038-1044. PMC: 7436499. DOI: 10.1002/jmv.26386. View

Mydam J, Younes L, Siddiqui M, Tarsha T . Death from COVID-19 in a Hispanic postpartum woman and review of the literature. BMJ Case Rep. 2021; 14(7). PMC: 8311310. DOI: 10.1136/bcr-2021-242819. View

Stanek J . Hypoxic patterns of placental injury: a review. Arch Pathol Lab Med. 2013; 137(5):706-20. DOI: 10.5858/arpa.2011-0645-RA. View

Loverro M, Damiani G, DI Naro E, Schonauer L, Laforgia N, Loverro M . Analysis of relation between placental lesions and perinatal outcome according to Amsterdam criteria: a comparative study. Acta Biomed. 2020; 91(3):e2020061. PMC: 7716953. DOI: 10.23750/abm.v91i3.8274. View

Stanek J, Al-Ahmadie H . Laminar necrosis of placental membranes: a histologic sign of uteroplacental hypoxia. Pediatr Dev Pathol. 2005; 8(1):34-42. DOI: 10.1007/s10024-004-8092-9. View

Goldenberg R, Faye-Petersen O, Andrews W, Goepfert A, Cliver S, Hauth J . The Alabama Preterm Birth Study: diffuse decidual leukocytoclastic necrosis of the decidua basalis, a placental lesion associated with preeclampsia, indicated preterm birth and decreased fetal growth. J Matern Fetal Neonatal Med. 2007; 20(5):391-5. DOI: 10.1080/14767050701236365. View

10.

Sharkey F, Prihoda T . Underreporting of placental abnormalities. Histopathology. 2009; 55(4):487-8. DOI: 10.1111/j.1365-2559.2009.03402.x. View

11.

Salafia C, Pezzullo J, Simmens S, Minior V, Vintzileos A . Placental pathologic features of preterm preeclampsia. Am J Obstet Gynecol. 1995; 173(4):1097-105. DOI: 10.1016/0002-9378(95)91333-5. View

12.

Marinho P, da Cunha A, Chimelli L, Avvad-Portari E, Da Matta Andreiuolo F, de Oliveira-Szejnfeld P . Case Report: SARS-CoV-2 Mother-to-Child Transmission and Fetal Death Associated With Severe Placental Thromboembolism. Front Med (Lausanne). 2021; 8:677001. PMC: 8415358. DOI: 10.3389/fmed.2021.677001. View

13.

Khong T, Mooney E, Ariel I, Balmus N, Boyd T, Brundler M . Sampling and Definitions of Placental Lesions: Amsterdam Placental Workshop Group Consensus Statement. Arch Pathol Lab Med. 2016; 140(7):698-713. DOI: 10.5858/arpa.2015-0225-CC. View

14.

Sharps M, Hayes D, Lee S, Zou Z, Brady C, Almoghrabi Y . A structured review of placental morphology and histopathological lesions associated with SARS-CoV-2 infection. Placenta. 2020; 101:13-29. PMC: 7443324. DOI: 10.1016/j.placenta.2020.08.018. View

15.

Bendon R, Coventry S, Reed R . Reassessing the clinical significance of chorionic membrane microcysts and linear necrosis. Pediatr Dev Pathol. 2012; 15(3):213-6. DOI: 10.2350/11-08-1072-OA.1. View