Innate Lymphoid Cells: Emerging Players in Pancreatic Disease

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Apr 12

PMID 35409105

Authors

Saimeng Shi

Longyun Ye

Kaizhou Jin

Zhiwen Xiao

Xianjun Yu

Weiding Wu

Affiliations

Soon will be listed here.

Abstract

Common pancreatic diseases have caused significant economic and social burdens worldwide. The interstitial microenvironment is involved in and plays a crucial part in the occurrence and progression of pancreatic diseases. Innate lymphoid cells (ILCs), an innate population of immune cells which have only gradually entered our visual field in the last 10 years, play an important role in maintaining tissue homeostasis, regulating metabolism, and participating in regeneration and repair. Recent evidence indicates that ILCs in the pancreas, as well as in other tissues, are also key players in pancreatic disease and health. Herein, we examined the possible functions of different ILC subsets in common pancreatic diseases, including diabetes mellitus, pancreatitis and pancreatic cancer, and discussed the potential practical implications of the relevant findings for future further treatment of these pancreatic diseases.

Citing Articles

Intestinal Mucosal Immune Barrier: A Powerful Firewall Against Severe Acute Pancreatitis-Associated Acute Lung Injury via the Gut-Lung Axis.

Li F, Wang Z, Cao Y, Pei B, Luo X, Liu J J Inflamm Res. 2024; 17:2173-2193.

PMID: 38617383 PMC: 11016262. DOI: 10.2147/JIR.S448819.

Adiponectin and Interleukin-33: Possible Early Markers of Metabolic Syndrome.

Nesic J, Ljujic B, Rosic V, Djukic A, Rosic M, Petrovic I J Clin Med. 2023; 12(1).

PMID: 36614933 PMC: 9821697. DOI: 10.3390/jcm12010132.

Innate lymphoid cells type 3 in cancer.

Castillo-Gonzalez R, Valle-Noguera A, Gomez-Sanchez M, Xia P, Cruz-Adalia A Front Immunol. 2022; 13:1033252.

PMID: 36341381 PMC: 9627779. DOI: 10.3389/fimmu.2022.1033252.

Innate lymphocytes: Role in alcohol-induced immune dysfunction.

Ruiz-Cortes K, Villageliu D, Samuelson D Front Immunol. 2022; 13:934617.

PMID: 36105802 PMC: 9464604. DOI: 10.3389/fimmu.2022.934617.

References

Hosein A, Brekken R, Maitra A . Pancreatic cancer stroma: an update on therapeutic targeting strategies. Nat Rev Gastroenterol Hepatol. 2020; 17(8):487-505. PMC: 8284850. DOI: 10.1038/s41575-020-0300-1. View

Qiu J, Zhou L . Aryl hydrocarbon receptor promotes RORγt⁺ group 3 ILCs and controls intestinal immunity and inflammation. Semin Immunopathol. 2013; 35(6):657-70. PMC: 3797199. DOI: 10.1007/s00281-013-0393-5. View

OSullivan T, Rapp M, Fan X, Weizman O, Bhardwaj P, Adams N . Adipose-Resident Group 1 Innate Lymphoid Cells Promote Obesity-Associated Insulin Resistance. Immunity. 2016; 45(2):428-41. PMC: 5004886. DOI: 10.1016/j.immuni.2016.06.016. View

Sendler M, van den Brandt C, Glaubitz J, Wilden A, Golchert J, Weiss F . NLRP3 Inflammasome Regulates Development of Systemic Inflammatory Response and Compensatory Anti-Inflammatory Response Syndromes in Mice With Acute Pancreatitis. Gastroenterology. 2019; 158(1):253-269.e14. DOI: 10.1053/j.gastro.2019.09.040. View

Nussbaum J, Van Dyken S, von Moltke J, Cheng L, Mohapatra A, Molofsky A . Type 2 innate lymphoid cells control eosinophil homeostasis. Nature. 2013; 502(7470):245-8. PMC: 3795960. DOI: 10.1038/nature12526. View

von Burg N, Turchinovich G, Finke D . Maintenance of Immune Homeostasis through ILC/T Cell Interactions. Front Immunol. 2015; 6:416. PMC: 4534831. DOI: 10.3389/fimmu.2015.00416. View

Taylor S, Huang Y, Mallett G, Stathopoulou C, Felizardo T, Sun M . PD-1 regulates KLRG1 group 2 innate lymphoid cells. J Exp Med. 2017; 214(6):1663-1678. PMC: 5461001. DOI: 10.1084/jem.20161653. View

Ohne Y, Silver J, Thompson-Snipes L, Collet M, Blanck J, Cantarel B . IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity. Nat Immunol. 2016; 17(6):646-55. DOI: 10.1038/ni.3447. View

Benezech C, Jackson-Jones L . ILC2 Orchestration of Local Immune Function in Adipose Tissue. Front Immunol. 2019; 10:171. PMC: 6374325. DOI: 10.3389/fimmu.2019.00171. View

10.

Neill D, Wong S, Bellosi A, Flynn R, Daly M, Langford T . Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature. 2010; 464(7293):1367-70. PMC: 2862165. DOI: 10.1038/nature08900. View

11.

Mylona V, Koussoulas V, Tzivras D, Makrygiannis E, Georgopoulou P, Koratzanis G . Changes in adaptive and innate immunity in patients with acute pancreatitis and systemic inflammatory response syndrome. Pancreatology. 2011; 11(5):475-81. DOI: 10.1159/000329460. View

12.

Molofsky A, Van Gool F, Liang H, Van Dyken S, Nussbaum J, Lee J . Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation. Immunity. 2015; 43(1):161-74. PMC: 4512852. DOI: 10.1016/j.immuni.2015.05.019. View

13.

Almaca J, Caicedo A, Landsman L . Beta cell dysfunction in diabetes: the islet microenvironment as an unusual suspect. Diabetologia. 2020; 63(10):2076-2085. PMC: 7655222. DOI: 10.1007/s00125-020-05186-5. View

14.

Withers D . Innate lymphoid cell regulation of adaptive immunity. Immunology. 2016; 149(2):123-30. PMC: 5011676. DOI: 10.1111/imm.12639. View

15.

Jacob N, Jaiswal S, Maheshwari D, Nallabelli N, Khatri N, Bhatia A . Butyrate induced Tregs are capable of migration from the GALT to the pancreas to restore immunological tolerance during type-1 diabetes. Sci Rep. 2020; 10(1):19120. PMC: 7644709. DOI: 10.1038/s41598-020-76109-y. View

16.

Spits H, Di Santo J . The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling. Nat Immunol. 2010; 12(1):21-7. DOI: 10.1038/ni.1962. View

17.

Boni-Schnetzler M, Boller S, Debray S, Bouzakri K, Meier D, Prazak R . Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I. Endocrinology. 2009; 150(12):5218-29. DOI: 10.1210/en.2009-0543. View

18.

Gasteiger G, Fan X, Dikiy S, Lee S, Rudensky A . Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs. Science. 2015; 350(6263):981-5. PMC: 4720139. DOI: 10.1126/science.aac9593. View

19.

Thompson R, Dong H, Lohse C, Leibovich B, Blute M, Cheville J . PD-1 is expressed by tumor-infiltrating immune cells and is associated with poor outcome for patients with renal cell carcinoma. Clin Cancer Res. 2007; 13(6):1757-61. DOI: 10.1158/1078-0432.CCR-06-2599. View

20.

Vivier E, Raulet D, Moretta A, Caligiuri M, Zitvogel L, Lanier L . Innate or adaptive immunity? The example of natural killer cells. Science. 2011; 331(6013):44-9. PMC: 3089969. DOI: 10.1126/science.1198687. View