Natural Small Molecules in Breast Cancer Treatment: Understandings from a Therapeutic Viewpoint

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2022 Apr 12

PMID 35408561

Authors

Md Rezaul Islam

Fahadul Islam

Mohamed H Nafady

Muniya Akter

Saikat Mitra

Rajib Das

Humaira Urmee

Sheikh Shohag

Aklima Akter

Kumarappan Chidambaram

Fahad A Alhumaydhi

Talha Bin Emran

Simona Cavalu

Affiliations

Soon will be listed here.

Abstract

Breast cancer (BrCa) is the most common malignancy in women and the second most significant cause of death from cancer. BrCa is one of the most challenging malignancies to treat, and it accounts for a large percentage of cancer-related deaths. The number of cases requiring more effective BrCa therapy has increased dramatically. Scientists are looking for more productive agents, such as organic combinations, for BrCa prevention and treatment because most chemotherapeutic agents are linked to cancer metastasis, the resistance of the drugs, and side effects. Natural compounds produced by living organisms promote apoptosis and inhibit metastasis, slowing the spread of cancer. As a result, these compounds may delay the spread of BrCa, enhancing survival rates and reducing the number of deaths caused by BrCa. Several natural compounds inhibit BrCa production while lowering cancer cell proliferation and triggering cell death. Natural compounds, in addition to therapeutic approaches, are efficient and potential agents for treating BrCa. This review highlights the natural compounds demonstrated in various studies to have anticancer properties in BrCa cells. Future research into biological anti-BrCa agents may pave the way for a new era in BrCa treatment, with natural anti-BrCa drugs playing a key role in improving BrCa patient survival rates.

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