Recent Advances in Copper-Doped Titanium Implants

Overview

Journal Materials (Basel)

Publisher MDPI

Date 2022 Apr 12

PMID 35407675

Authors

Yuncheng Wu

Hao Zhou

Ye Zeng

Hongxing Xie

Dongxu Ma

Zhoucheng Wang

Hanfeng Liang

Affiliations

Soon will be listed here.

Abstract

Titanium (Ti) and its alloys have been extensively used as implant materials in clinical practice due to their high corrosion resistance, light weight and excellent biocompatibility. However, the insufficient intrinsic osteogenic capacity of Ti and its alloys impedes bone repair and regeneration, and implant-related infection or inflammation remains the leading cause of implant failure. Bacterial infections or inflammatory diseases constitute severe threats to human health. The physicochemical properties of the material are critical to the success of clinical procedures, and the doping of Cu into Ti implants has been confirmed to be capable of enhancing the bone repair/regeneration, angiogenesis and antibacterial capability. This review outlines the recent advances in the design and preparation of Cu-doped Ti and Ti alloy implants, with a special focus on various methods, including plasma immersion implantation, magnetron sputtering, galvanic deposition, microarc oxidation and sol-gel synthesis. More importantly, the antibacterial and mechanical properties as well as the corrosion resistance and biocompatibility of Cu-doped Ti implants from different methods are systematically reviewed, and their prospects and limitations are also discussed.

Citing Articles

Cuproptosis Cell Death Molecular Events and Pathways to Liver Disease.

Mao Y, Chen H, Zhu W, Ni S, Luo S, Tang S J Inflamm Res. 2025; 18:883-894.

PMID: 39867947 PMC: 11760270. DOI: 10.2147/JIR.S498340.

Photothermal Coating on Zinc Alloy for Controlled Biodegradation and Improved Osseointegration.

Hsu Y, He Y, Zhao X, Wang F, Yang F, Zheng Y Adv Sci (Weinh). 2025; 12(9):e2409051.

PMID: 39807526 PMC: 11884568. DOI: 10.1002/advs.202409051.

A Comprehensive Review of the Contemporary Methods for Enhancing Osseointegration and the Antimicrobial Properties of Titanium Dental Implants.

Bakitian F Cureus. 2024; 16(9):e68720.

PMID: 39238921 PMC: 11376426. DOI: 10.7759/cureus.68720.

Nucleation and growth process of a softened-spark layer during microarc oxidation on a selective laser melted Ti alloy.

Li D, Lin H, Wang X, Li M, Wang B, Zhou Z RSC Adv. 2024; 14(36):25975-25985.

PMID: 39161444 PMC: 11331398. DOI: 10.1039/d4ra04704d.

Various Antibacterial Strategies Utilizing Titanium Dioxide Nanotubes Prepared via Electrochemical Anodization Biofabrication Method.

Wang W, Liu H, Guo Z, Hu Z, Wang K, Leng Y Biomimetics (Basel). 2024; 9(7).

PMID: 39056849 PMC: 11274689. DOI: 10.3390/biomimetics9070408.

References

Krakhmalev P, Yadroitsev I, Yadroitsava I, de Smidt O . Functionalization of Biomedical Ti6Al4V via In Situ Alloying by Cu during Laser Powder Bed Fusion Manufacturing. Materials (Basel). 2017; 10(10). PMC: 5666960. DOI: 10.3390/ma10101154. View

Xia C, Ma X, Zhang X, Li K, Tan J, Qiao Y . Enhanced physicochemical and biological properties of C/Cu dual ions implanted medical titanium. Bioact Mater. 2020; 5(2):377-386. PMC: 7083793. DOI: 10.1016/j.bioactmat.2020.02.017. View

Zheng Y, Li J, Liu X, Sun J . Antimicrobial and osteogenic effect of Ag-implanted titanium with a nanostructured surface. Int J Nanomedicine. 2012; 7:875-84. PMC: 3289444. DOI: 10.2147/IJN.S28450. View

Glauser R, Schupbach P, Gottlow J, Hammerle C . Periimplant soft tissue barrier at experimental one-piece mini-implants with different surface topography in humans: A light-microscopic overview and histometric analysis. Clin Implant Dent Relat Res. 2005; 7 Suppl 1:S44-51. DOI: 10.1111/j.1708-8208.2005.tb00074.x. View

Liu R, Ma Z, Kolawole S, Zeng L, Zhao Y, Ren L . In vitro study on cytocompatibility and osteogenesis ability of Ti-Cu alloy. J Mater Sci Mater Med. 2019; 30(7):75. DOI: 10.1007/s10856-019-6277-z. View

Johnson L, Hug L . Distribution of reactive oxygen species defense mechanisms across domain bacteria. Free Radic Biol Med. 2019; 140:93-102. DOI: 10.1016/j.freeradbiomed.2019.03.032. View

Issa Y, Brunton P, Waters C, Watts D . Cytotoxicity of metal ions to human oligodendroglial cells and human gingival fibroblasts assessed by mitochondrial dehydrogenase activity. Dent Mater. 2007; 24(2):281-7. DOI: 10.1016/j.dental.2007.09.010. View

Shimabukuro M . Antibacterial Property and Biocompatibility of Silver, Copper, and Zinc in Titanium Dioxide Layers Incorporated by One-Step Micro-Arc Oxidation: A Review. Antibiotics (Basel). 2020; 9(10). PMC: 7589568. DOI: 10.3390/antibiotics9100716. View

Yao Z, Ivanisenko Y, Diemant T, Caron A, Chuvilin A, Jiang J . Synthesis and properties of hydroxyapatite-containing porous titania coating on ultrafine-grained titanium by micro-arc oxidation. Acta Biomater. 2010; 6(7):2816-25. DOI: 10.1016/j.actbio.2009.12.053. View

10.

Li J, Wang G, Zhu H, Zhang M, Zheng X, Di Z . Antibacterial activity of large-area monolayer graphene film manipulated by charge transfer. Sci Rep. 2014; 4:4359. PMC: 3950808. DOI: 10.1038/srep04359. View

11.

Mirastschijski U, Martin A, Jorgensen L, Sampson B, Agren M . Zinc, copper, and selenium tissue levels and their relation to subcutaneous abscess, minor surgery, and wound healing in humans. Biol Trace Elem Res. 2013; 153(1-3):76-83. DOI: 10.1007/s12011-013-9658-z. View

12.

Sasani N, Vahdati Khaki J, Zebarjad S . Characterization and nanomechanical properties of novel dental implant coatings containing copper decorated-carbon nanotubes. J Mech Behav Biomed Mater. 2014; 37:125-32. DOI: 10.1016/j.jmbbm.2014.05.003. View

13.

Zhao Q, Yi L, Hu A, Jiang L, Hong L, Dong J . Antibacterial and osteogenic activity of a multifunctional microporous coating codoped with Mg, Cu and F on titanium. J Mater Chem B. 2020; 7(14):2284-2299. DOI: 10.1039/c8tb03377c. View

14.

Zong M, Bai L, Liu Y, Wang X, Zhang X, Huang X . Antibacterial ability and angiogenic activity of Cu-Ti-O nanotube arrays. Mater Sci Eng C Mater Biol Appl. 2016; 71:93-99. DOI: 10.1016/j.msec.2016.09.077. View

15.

Stewart P, Costerton J . Antibiotic resistance of bacteria in biofilms. Lancet. 2001; 358(9276):135-8. DOI: 10.1016/s0140-6736(01)05321-1. View

16.

Liu H, Tang Y, Zhang S, Liu H, Wang Z, Li Y . Anti-infection mechanism of a novel dental implant made of titanium-copper (TiCu) alloy and its mechanism associated with oral microbiology. Bioact Mater. 2021; 8:381-395. PMC: 8429474. DOI: 10.1016/j.bioactmat.2021.05.053. View

17.

Zhang X, Li J, Wang X, Wang Y, Hang R, Huang X . Effects of copper nanoparticles in porous TiO coatings on bacterial resistance and cytocompatibility of osteoblasts and endothelial cells. Mater Sci Eng C Mater Biol Appl. 2017; 82:110-120. DOI: 10.1016/j.msec.2017.08.061. View

18.

Campoccia D, Montanaro L, Arciola C . The significance of infection related to orthopedic devices and issues of antibiotic resistance. Biomaterials. 2005; 27(11):2331-9. DOI: 10.1016/j.biomaterials.2005.11.044. View

19.

Xu N, Cheng H, Xu J, Li F, Gao B, Li Z . Silver-loaded nanotubular structures enhanced bactericidal efficiency of antibiotics with synergistic effect in vitro and in vivo. Int J Nanomedicine. 2017; 12:731-743. PMC: 5291465. DOI: 10.2147/IJN.S123648. View

20.

Dibart S, Warbington M, Su M, Skobe Z . In vitro evaluation of the implant-abutment bacterial seal: the locking taper system. Int J Oral Maxillofac Implants. 2005; 20(5):732-7. View