Care Management and Survival of Patients Diagnosed with Synchronous Metastatic Colorectal Cancer: A High-Resolution Population-Based Study in Two French Areas

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2022 Apr 12

PMID 35406549

Authors

Andrea Mulliri

Josephine Gardy

Melanie Cariou

Guy Launoy

Michel Robaszkiewicz

Arnaud Alves

Veronique Bouvier

Olivier Dejardin

Affiliations

Soon will be listed here.

Abstract

Methods: All CRC cases with SM diagnosed between 2006 and 2016 ( = 3062) were selected from two specialized digestive cancer registries from northwest France. Cox regression analysis was used to assess survival. Multivariable logistic regression was used to examine factors related to the combination of PTR and CT.

Results: The longest survival was observed in patients treated by PTR combined with CT (Group 4; = 1159). Overall survival was 51.80% at one year (95% Confidence Interval (CI) 50.00-53.60%) and 9.40% at five years (95% CI, 8.30-10.60%). Survival did not differ with respect to the order of treatment in multivariable analysis (hazard ratio, 1.05; 95% CI, 0.88-1.24; = 0.55).

Conclusion: Regardless of the sequence of treatment, a PTR + CT offered the best survival in patients with CRC and SM, even though few were eligible for combination therapy (38%).

Citing Articles

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PMID: 38358541 PMC: 10869323. DOI: 10.1186/s40658-023-00597-w.

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