Propofol + Granisetron Vs. Propofol + Metoclopramide in Symptom Management of Acute Migraine Headache; a Double-Blind Randomized Clinical Trial

Overview

Journal Arch Acad Emerg Med

Specialty Emergency Medicine

Date 2022 Apr 11

PMID 35402989

Authors

Samaneh Abiri

Mehdi Chegin

Reza Soleimani

Naser Hatami

Navid Kalani

Esmail Rayatdoost

Affiliations

Soon will be listed here.

Abstract

Introduction: Acute headache is one of the most common reasons for emergency department (ED) visits. This study aimed to compare the combination of propofol and granisetron with propofol and metoclopramide in symptom management of acute migraine headache.

Methods: In this double-blind randomized clinical trial, 60 adult patients with acute migraine headache who referred to ED were randomly divided into two groups of propofol + metoclopramide and propofol + granisetron. Pain and nausea/vomiting severity as well as blood pressure were compared between groups 30, 45, and 60 minutes after treatment.

Results: The two groups had similar situation regarding mean age (p = 0.606), sex distribution (p = 0.793), baseline severity of pain (p = 0.642), frequency of nausea/vomiting (p = 0.488), and vital signs (p > 0.05). The severity of pain was similar in the two groups 30 (p = 0.731), 45 (p = 0.460), and 60 (p = 0.712) minutes after treatment. The number of patients with resistant nausea and vomiting 60 minutes after treatment was significantly higher in metoclopramide group (30.0% versus 10.0%; p = 0.033). Diastolic pressure 60 minutes after treatment (81.43 ±8.94 vs. 74.97 ± 4.8; p = 0.001) and heart rate 30 minutes after treatment (68.87 ±6.52 vs. 73.57± 7.62; p = 0.013) had statistically significant differences between the groups.

Conclusion: The combination of propofol and granisetron was superior to propofol and metoclopramide in case of controlling nausea and vomiting of cases with acute migraine headache; meanwhile, no differences were observed in case of pain relief and hemodynamic status between the two groups.

Citing Articles

Analysis of articles in the Journal of Archives of Academic Emergency Medicine in 2022.

Saghaei Dehkordi S, Yazdanbakhsh M Arch Acad Emerg Med. 2023; 11(1):e3.

PMID: 36620732 PMC: 9807955. DOI: 10.22037/aaem.v11i1.1882.

Pathophysiology and Therapy of Associated Features of Migraine.

Villar-Martinez M, Goadsby P Cells. 2022; 11(17).

PMID: 36078174 PMC: 9455236. DOI: 10.3390/cells11172767.

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