Abnormal Bone Marrow Microenvironment: the "harbor" of Acute Lymphoblastic Leukemia Cells

Overview

Journal Blood Sci

Date 2022 Apr 11

PMID 35402834

Authors

Zehui Chen

Yaxin Zheng

Yaling Yang

Junnan Kang

M James You

Chen Tian

Affiliations

Soon will be listed here.

Abstract

Bone marrow (BM) microenvironment regulates and supports the production of blood cells which are necessary to maintain homeostasis. In analogy to normal hematopoiesis, leukemogenesis is originated from leukemic stem cells (LSCs) which gives rise to more differentiated malignant cells. Leukemia cells occupy BM niches and reconstruct them to support leukemogenesis. The abnormal BM niches are the main sanctuary of LSCs where they can evade chemotherapy-induced death and acquire drug resistance. In this review, we focus on the protective effects of BM niche cells on acute lymphoblastic leukemia cells.

Citing Articles

Mechanisms of Immunosuppressive Tumor Evasion: Focus on Acute Lymphoblastic Leukemia.

Jimenez-Morales S, Aranda-Uribe I, Perez-Amado C, Ramirez-Bello J, Hidalgo-Miranda A Front Immunol. 2021; 12:737340.

PMID: 34867958 PMC: 8636671. DOI: 10.3389/fimmu.2021.737340.

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