The Regulators of BCR Signaling During B Cell Activation

Overview

Journal Blood Sci

Date 2022 Apr 11

PMID 35402811

Authors

Yue Wen

Yukai Jing

Lu Yang

Danqing Kang

Panpan Jiang

Na Li

Jiali Cheng

Jingwen Li

Xingbo Li

Zican Peng

Xizi Sun

Heather Miller

Zhiwei Sui

Quan Gong

Boxu Ren

Wei Yin

Chaohong Liu

Affiliations

Soon will be listed here.

Abstract

B lymphocytes produce antibodies under the stimulation of specific antigens, thereby exerting an immune effect. B cells identify antigens by their surface B cell receptor (BCR), which upon stimulation, directs the cell to activate and differentiate into antibody generating plasma cells. Activation of B cells via their BCRs involves signaling pathways that are tightly controlled by various regulators. In this review, we will discuss three major BCR mediated signaling pathways (the PLC-γ2 pathway, PI3K pathway and MAPK pathway) and related regulators, which were roughly divided into positive, negative and mutual-balanced regulators, and the specific regulators of the specific signaling pathway based on regulatory effects.

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