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Kratom ()-Induced Hepatitis

Overview
Journal ACG Case Rep J
Specialty Gastroenterology
Date 2022 Apr 11
PMID 35399621
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Abstract

Kratom is a plant with opioid-like properties known to produce stimulant and analgesic effects. Although there are numerous studies on the psychoactive components of kratom, less is known about the toxicity. Specifically, few reports describe kratom-induced hepatotoxicity and demonstrate histological features. We provide a case report detailing the clinicopathologic findings of drug-induced liver injury caused by kratom. The laboratory workup included significant elevation of total bilirubin and alkaline phosphatase. Liver biopsy demonstrated a prominent canalicular cholestatic pattern, mixed portal inflammation, and newly described perivenular necrosis. This report provides additional information on kratom toxicity because its use continues to rise.

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References
1.
Osborne C, Overstreet A, Rockey D, Schreiner A . Drug-Induced Liver Injury Caused by Kratom Use as an Alternative Pain Treatment Amid an Ongoing Opioid Epidemic. J Investig Med High Impact Case Rep. 2019; 7:2324709619826167. PMC: 6350132. DOI: 10.1177/2324709619826167. View

2.
Kamble S, Sharma A, King T, Berthold E, Leon F, Meyer P . Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids. Toxicol Lett. 2019; 319:148-154. PMC: 7902086. DOI: 10.1016/j.toxlet.2019.11.005. View

3.
Fernandes C, Iqbal U, Tighe S, Ahmed A . Kratom-Induced Cholestatic Liver Injury and Its Conservative Management. J Investig Med High Impact Case Rep. 2019; 7:2324709619836138. PMC: 6440031. DOI: 10.1177/2324709619836138. View

4.
Eggleston W, Stoppacher R, Suen K, Marraffa J, Nelson L . Kratom Use and Toxicities in the United States. Pharmacotherapy. 2019; 39(7):775-777. DOI: 10.1002/phar.2280. View

5.
Veltri C, Grundmann O . Current perspectives on the impact of Kratom use. Subst Abuse Rehabil. 2019; 10:23-31. PMC: 6612999. DOI: 10.2147/SAR.S164261. View