Pulmonary Hypertension Among Maintenance Hemodialysis Patients in Somalia: a Hospital-based Observational Study

Overview

Journal Egypt Heart J

Publisher Springer

Specialty Cardiology & Vascular Diseases

Date 2022 Apr 8

PMID 35394597

Authors

Gokhan Alici

Mohamud Mire Waberi

Mohamed Abdullahi Mohamud

Ahmed Muhammad Bashir

Omer Genc

Affiliations

Soon will be listed here.

Abstract

Background: This study aims to examine the prevalence and related factors of pulmonary hypertension (PHT) in patients on hemodialysis (HD) at the only referral institution in Somalia. A total of one hundred and forty-three patients who had received regular HD therapy for at least three months and underwent transthoracic echocardiography (TTE) were included in the study. Patients with a systolic pulmonary artery pressure (sPAP) value > 35 mmHg at rest on TTE were considered having PHT. The relationship of TTE parameters, demographic, and clinic characteristics of participants with PHT were evaluated.

Results: The number of patients with PHT was 73 (51%). The mean age was 54.2 ± 18.4 years. The majority of patients were 65 years of age or older. (n: 46, 32.2%) and 65 (45.5%) were male. Median sPAP was found to be 35 mmHg. Systolic pulmonary artery pressure was positively correlated with right atrium (RA) diameter (r: 0.6, p < 0.001) and negatively correlated with left ventricular ejection fraction (LVEF) (r: - 0.4, p < 0.001). In addition, LVEF, RA diameter, presence of pericardial effusion (PE) were found to be independent predictors of PHT.

Conclusions: Pulmonary hypertension has a relatively high prevalence in end-stage renal disease (ESRD) patients on regular HD. Besides, the presence of PE and certain right and left heart parameters were independently associated with PHT.

Citing Articles

Pulmonary Hypertension in Hemodialysis Patients and Its Determinants: A Hospital Based Cross-Sectional Study.

Yu Q, Zhang Q Int J Gen Med. 2024; 17:3919-3926.

PMID: 39268178 PMC: 11390829. DOI: 10.2147/IJGM.S471779.

Chest X-ray Findings and Prognostic Factors in Survival Analysis in Peritoneal Dialysis and Hemodialysis Patients: A Retrospective Cross-Sectional Study.

Tabakoglu N, Hatipoglu O Medicina (Kaunas). 2024; 60(8).

PMID: 39202612 PMC: 11356292. DOI: 10.3390/medicina60081331.

Predictors, prevalence and prognostic role of pulmonary hypertension in patients with chronic kidney disease: a systematic review and meta-analysis.

Lin C, Ge Q, Wang L, Zeng P, Huang M, Li D Ren Fail. 2024; 46(2):2368082.

PMID: 38938193 PMC: 11216249. DOI: 10.1080/0886022X.2024.2368082.

Frequency of Pulmonary Hypertension and Its Associated Risk Factors in End-Stage Renal Disease (ESRD) Patients on Maintenance Hemodialysis.

Khemchandani M, Nasir K, Qureshi R, Dhrolia M, Ahmad A Cureus. 2024; 16(2):e55206.

PMID: 38558648 PMC: 10981504. DOI: 10.7759/cureus.55206.

References

Alici G, Genc O . Prevalence and etiologies of pulmonary hypertension at Somalia-Turkey Training and Research Hospital in Mogadishu. Pan Afr Med J. 2022; 40:215. PMC: 8783313. DOI: 10.11604/pamj.2021.40.215.30159. View

Raymond R, Hinderliter A, Willis P, Ralph D, Caldwell E, Williams W . Echocardiographic predictors of adverse outcomes in primary pulmonary hypertension. J Am Coll Cardiol. 2002; 39(7):1214-9. DOI: 10.1016/s0735-1097(02)01744-8. View

OLeary J, Assad T, Xu M, Birdwell K, Farber-Eger E, Wells Q . Pulmonary hypertension in patients with chronic kidney disease: invasive hemodynamic etiology and outcomes. Pulm Circ. 2017; 7(3):674-683. PMC: 5841902. DOI: 10.1177/2045893217716108. View

Maron B, Brittain E, Choudhary G, Gladwin M . Redefining pulmonary hypertension. Lancet Respir Med. 2017; 6(3):168-170. DOI: 10.1016/S2213-2600(17)30498-8. View

Alpert M, Ravenscraft M . Pericardial involvement in end-stage renal disease. Am J Med Sci. 2003; 325(4):228-36. DOI: 10.1097/00000441-200304000-00009. View

Sato T, Tsujino I, Oyama-Manabe N, Ohira H, Ito Y, Yamada A . Right atrial volume and phasic function in pulmonary hypertension. Int J Cardiol. 2012; 168(1):420-6. DOI: 10.1016/j.ijcard.2012.09.133. View

Mousavi S, Mahdavi-Mazdeh M, Yahyazadeh H, Azadi M, Rahimzadeh N, Yoosefnejad H . Pulmonary hypertension and predisposing factors in patients receiving hemodialysis. Iran J Kidney Dis. 2009; 2(1):29-33. View

Hayati F, Beladi Mousavi S, Mousavi Movahed S, Mofrad Bushehri M . Pulmonary hypertension among patients undergoing hemodialysis. J Renal Inj Prev. 2017; 6(2):122-126. PMC: 5423279. DOI: 10.15171/jrip.2017.24. View

Fadaii A, Koohi-Kamali H, Bagheri B, Hamidimanii F, Taherkhanchi B . Prevalence of pulmonary hypertension in patients undergoing hemodialysis. Iran J Kidney Dis. 2013; 7(1):60-3. View

10.

Bolignano D, Pisano A, Coppolino G, Tripepi G, DArrigo G . Pulmonary Hypertension Predicts Adverse Outcomes in Renal Patients: A Systematic Review and Meta-Analysis. Ther Apher Dial. 2018; 23(4):369-384. DOI: 10.1111/1744-9987.12777. View

11.

Navaneethan S, Roy J, Tao K, Brecklin C, Chen J, Deo R . Prevalence, Predictors, and Outcomes of Pulmonary Hypertension in CKD. J Am Soc Nephrol. 2015; 27(3):877-86. PMC: 4769189. DOI: 10.1681/ASN.2014111111. View

12.

Genctoy G, Arikan S, Eldem O . Pulmonary hypertension associates with malnutrition and body composition hemodialysis patients. Ren Fail. 2014; 37(2):273-9. DOI: 10.3109/0886022X.2014.986705. View

13.

Simonneau G, Montani D, Celermajer D, Denton C, Gatzoulis M, Krowka M . Haemodynamic definitions and updated clinical classification of pulmonary hypertension. Eur Respir J. 2018; 53(1). PMC: 6351336. DOI: 10.1183/13993003.01913-2018. View

14.

Barbera J, Roman A, Gomez-Sanchez M, Blanco I, Otero R, Lopez-Reyes R . Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Summary of Recommendations. Arch Bronconeumol (Engl Ed). 2018; 54(4):205-215. DOI: 10.1016/j.arbres.2017.11.014. View

15.

Batal O, Dardari Z, Costabile C, Gorcsan J, Arena V, Mathier M . Prognostic Value of Pericardial Effusion on Serial Echocardiograms in Pulmonary Arterial Hypertension. Echocardiography. 2015; 32(10):1471-6. DOI: 10.1111/echo.12909. View

16.

Hansrivijit P, Chen Y, Lnu K, Trongtorsak A, Puthenpura M, Thongprayoon C . Prediction of mortality among patients with chronic kidney disease: A systematic review. World J Nephrol. 2021; 10(4):59-75. PMC: 8353601. DOI: 10.5527/wjn.v10.i4.59. View

17.

Alici G, Genc O . Spectrum of cardiovascular diseases at a referral tertiary care hospital in Somalia, Mogadishu: an echocardiographic study. BMC Cardiovasc Disord. 2021; 21(1):599. PMC: 8680378. DOI: 10.1186/s12872-021-02417-4. View

18.

Rehman K, Betancor J, Xu B, Kumar A, Rivas C, Sato K . Uremic pericarditis, pericardial effusion, and constrictive pericarditis in end-stage renal disease: Insights and pathophysiology. Clin Cardiol. 2017; 40(10):839-846. PMC: 6490618. DOI: 10.1002/clc.22770. View

19.

Yoo H, Reis R, Telini W, Telini L, Hueb J, Bazan S . Association of Pulmonary Hypertension With Inflammation and Fluid Overload in Hemodialysis Patients. Iran J Kidney Dis. 2017; 11(4):303-308. View

20.

Zhang Y, Ding X, Rao R, Wang Y, Pang F, Tang S . The Prevalence of Pulmonary Hypertension Among Maintenance Dialysis Patients With ESRD and Its Associated Factors: A Retrospective Study. Front Med (Lausanne). 2020; 7:570874. PMC: 7746851. DOI: 10.3389/fmed.2020.570874. View