The Inhibitory Effect and Mechanism of Volatile Oil on Gastric Cancer

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2022 Apr 8

PMID 35392643

Authors

Rong Han

Yun Sun

Ruoting Ma

Dexi Wang

Jianan Sun

Shengjun Zhao

Haiying Zhang

Affiliations

Soon will be listed here.

Abstract

volatile oil (FAVO) has a good inhibitory activity on gastric cancer cell proliferation, but the mechanism of action is not yet clear. In this study, we tested the antigastric cancer efficacy and mechanism of FAVO using both and models. The results showed that FAVO effectively inhibited the proliferation, migration, and invasion of human gastric cancer SGC-7901 cells, the formation of small tubules of human umbilical vein endothelial cells as well as zebrafish intersegmental vessel and intestinal vein angiogenesis. experiments showed that FAVO significantly delayed the growth of SGC-7901 tumor-bearing nude mice and induced higher serum IL-2 and IFN- and reduced serum IL-6. Western blot results showed that FAVO reduced the expression of HIF-2, VEGF, VEGFR2, P-VEGFR2, Akt, and P-Akt in SGC-7901 cells with CoCl induced hypoxia. We further clarified the main chemical components of FAVO through GC-MS analysis. In summary, FAVO may inhibit tumor growth and angiogenesis via inhibiting the HIF-2/VEGF signaling pathway.

References

Wu D, Potluri N, Lu J, Kim Y, Rastinejad F . Structural integration in hypoxia-inducible factors. Nature. 2015; 524(7565):303-8. DOI: 10.1038/nature14883. View

Cho H, Du X, Rizzi J, Liberzon E, Chakraborty A, Gao W . On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models. Nature. 2016; 539(7627):107-111. PMC: 5499381. DOI: 10.1038/nature19795. View

Rios-Navarro C, Hueso L, Diaz A, Marcos-Garces V, Bonanad C, Ruiz-Sauri A . Role of antiangiogenic VEGF-Ab in angiogenesis and systolic function after reperfused myocardial infarction. Rev Esp Cardiol (Engl Ed). 2020; 74(2):131-139. DOI: 10.1016/j.rec.2020.03.013. View

Utegenova G, Pallister K, Kushnarenko S, Ozek G, Ozek T, Abidkulova K . Chemical Composition and Antibacterial Activity of Essential Oils from L. Species against Methicillin-Resistant . Molecules. 2018; 23(7). PMC: 6099696. DOI: 10.3390/molecules23071679. View

Lopes J, Fisher J, Flick H, Wang C, Sun L, Ernstoff M . ALKS 4230: a novel engineered IL-2 fusion protein with an improved cellular selectivity profile for cancer immunotherapy. J Immunother Cancer. 2020; 8(1). PMC: 7204809. DOI: 10.1136/jitc-2020-000673. View

Yang J, Yan J, Shao J, Xu Q, Meng F, Chen F . Immune-Mediated Antitumor Effect By VEGFR2 Selective Inhibitor For Gastric Cancer. Onco Targets Ther. 2019; 12:9757-9765. PMC: 6863181. DOI: 10.2147/OTT.S233496. View

Schepetkin I, Kushnarenko S, Ozek G, Kirpotina L, Sinharoy P, Utegenova G . Modulation of Human Neutrophil Responses by the Essential Oils from Ferula akitschkensis and Their Constituents. J Agric Food Chem. 2016; 64(38):7156-70. PMC: 5048753. DOI: 10.1021/acs.jafc.6b03205. View

Liu C, He L, Wang J, Wang Q, Sun C, Li Y . Anti-angiogenic effect of Shikonin in rheumatoid arthritis by downregulating PI3K/AKT and MAPKs signaling pathways. J Ethnopharmacol. 2020; 260:113039. DOI: 10.1016/j.jep.2020.113039. View

Jin Y, Che X, Qu X, Li X, Lu W, Wu J . CircHIPK3 Promotes Metastasis of Gastric Cancer via miR-653-5p/miR-338-3p-NRP1 Axis Under a Long-Term Hypoxic Microenvironment. Front Oncol. 2020; 10:1612. PMC: 7443574. DOI: 10.3389/fonc.2020.01612. View

10.

Wang R, Miao R, Zhang X, Yang G, Mu Y, Zhang Z . Fork head box M1 regulates vascular endothelial growth factor-A expression to promote the angiogenesis and tumor cell growth of gallbladder cancer. World J Gastroenterol. 2021; 27(8):692-707. PMC: 7934001. DOI: 10.3748/wjg.v27.i8.692. View

11.

Cowman S, Fuja D, Liu X, Slack Tidwell R, Kandula N, Sirohi D . Macrophage HIF-1α Is an Independent Prognostic Indicator in Kidney Cancer. Clin Cancer Res. 2020; 26(18):4970-4982. PMC: 7968518. DOI: 10.1158/1078-0432.CCR-19-3890. View

12.

Jalili-Nik M, Sabri H, Zamiri E, Soukhtanloo M, Karimi Roshan M, Hosseini A . Cytotoxic Effects of Ferula Latisecta on Human Glioma U87 Cells. Drug Res (Stuttg). 2019; 69(12):665-670. DOI: 10.1055/a-0986-6543. View

13.

Shi L, Sheng J, Chen G, Zhu P, Shi C, Li B . Combining IL-2-based immunotherapy with commensal probiotics produces enhanced antitumor immune response and tumor clearance. J Immunother Cancer. 2020; 8(2). PMC: 7542661. DOI: 10.1136/jitc-2020-000973. View

14.

Sun X, Meng L, Qiao W, Yang R, Gao Q, Peng Y . Vascular endothelial growth factor A/Vascular endothelial growth factor receptor 2 axis promotes human dental pulp stem cell migration via the FAK/PI3K/Akt and p38 MAPK signalling pathways. Int Endod J. 2019; 52(12):1691-1703. DOI: 10.1111/iej.13179. View

15.

Moreno Roig E, Groot A, Yaromina A, Hendrickx T, Barbeau L, Giuranno L . HIF-1α and HIF-2α Differently Regulate the Radiation Sensitivity of NSCLC Cells. Cells. 2019; 8(1). PMC: 6356534. DOI: 10.3390/cells8010045. View

16.

Hao Y, Yan Z, Zhang A, Hu S, Wang N, Luo X . IL-6/STAT3 mediates the HPV18 E6/E7 stimulated upregulation of MALAT1 gene in cervical cancer HeLa cells. Virus Res. 2020; 281:197907. DOI: 10.1016/j.virusres.2020.197907. View

17.

Lian X, Zhang H, Liu Q, Lu X, Zhou P, He S . Ovarian cancer-excreted exosomal miR-199a-5p suppresses tumor metastasis by targeting hypoxia-inducible factor-2α in hypoxia microenvironment. Cancer Commun (Lond). 2020; 40(8):380-385. PMC: 7427304. DOI: 10.1002/cac2.12034. View

18.

Asemani Y, Azadmehr A, Hajiaghaee R, Amirghofran Z . Anticancer potential of Ferula hezarlalehzarica Y. Ajani fraction in Raji lymphoma cell line: induction of apoptosis, cell cycle arrest, and changes in mitochondrial membrane potential. Daru. 2018; 26(2):143-154. PMC: 6279669. DOI: 10.1007/s40199-018-0219-z. View

19.

Huang C, Huang J, Yu G . Co-suppression of VEGF-A and VEGF-C inhibits development of experimental hemangioma. Am J Transl Res. 2018; 10(9):2911-2919. PMC: 6176239. View

20.

Lopez-Ferreras L, Longo F, Richard J, Eerola K, Shevchouk O, Tuzinovic M . Key role for hypothalamic interleukin-6 in food-motivated behavior and body weight regulation. Psychoneuroendocrinology. 2021; 131:105284. DOI: 10.1016/j.psyneuen.2021.105284. View