PH-Responsive Polymer Nanomaterials for Tumor Therapy

Overview

Journal Front Oncol

Specialty Oncology

Date 2022 Apr 8

PMID 35392227

Authors

Shunli Chu

Xiaolu Shi

Ye Tian

Fengxiang Gao

Affiliations

Soon will be listed here.

Abstract

The complexity of the tumor microenvironment presents significant challenges to cancer therapy, while providing opportunities for targeted drug delivery. Using characteristic signals of the tumor microenvironment, various stimuli-responsive drug delivery systems can be constructed for targeted drug delivery to tumor sites. Among these, the pH is frequently utilized, owing to the pH of the tumor microenvironment being lower than that of blood and healthy tissues. pH-responsive polymer carriers can improve the efficiency of drug delivery , allow targeted drug delivery, and reduce adverse drug reactions, enabling multifunctional and personalized treatment. pH-responsive polymers have gained increasing interest due to their advantageous properties and potential for applicability in tumor therapy. In this review, recent advances in, and common applications of, pH-responsive polymer nanomaterials for drug delivery in cancer therapy are summarized, with a focus on the different types of pH-responsive polymers. Moreover, the challenges and future applications in this field are prospected.

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References

He L, Fullenkamp D, Rivera J, Messersmith P . pH responsive self-healing hydrogels formed by boronate-catechol complexation. Chem Commun (Camb). 2011; 47(26):7497-9. PMC: 4526106. DOI: 10.1039/c1cc11928a. View

He C, Hu Y, Yin L, Tang C, Yin C . Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles. Biomaterials. 2010; 31(13):3657-66. DOI: 10.1016/j.biomaterials.2010.01.065. View

Wang Z, Chen C, Zhang Q, Gao M, Zhang J, Kong D . Tuning the architecture of polymeric conjugate to mediate intracellular delivery of pleiotropic curcumin. Eur J Pharm Biopharm. 2014; 90:53-62. DOI: 10.1016/j.ejpb.2014.11.002. View

Ji T, Zhao Y, Ding Y, Nie G . Using functional nanomaterials to target and regulate the tumor microenvironment: diagnostic and therapeutic applications. Adv Mater. 2013; 25(26):3508-25. DOI: 10.1002/adma.201300299. View

Gopal V, Dubashi B, Kayal S, Penumadu P, Rajaram M, Karunanithi G . Challenges in the Management of Lung Cancer: Real-World Experience from a Tertiary Center in South India. South Asian J Cancer. 2021; 10(3):175-182. PMC: 8687871. DOI: 10.1055/s-0041-1733312. View

Cai S, Thati S, Bagby T, Diab H, Davies N, Cohen M . Localized doxorubicin chemotherapy with a biopolymeric nanocarrier improves survival and reduces toxicity in xenografts of human breast cancer. J Control Release. 2010; 146(2):212-8. PMC: 2918704. DOI: 10.1016/j.jconrel.2010.04.006. View

Aryal S, Hu C, Zhang L . Polymer--cisplatin conjugate nanoparticles for acid-responsive drug delivery. ACS Nano. 2009; 4(1):251-8. PMC: 2830398. DOI: 10.1021/nn9014032. View

Don T, Lu K, Lin L, Hsu C, Wu J, Mi F . Temperature/pH/Enzyme Triple-Responsive Cationic Protein/PAA-b-PNIPAAm Nanogels for Controlled Anticancer Drug and Photosensitizer Delivery against Multidrug Resistant Breast Cancer Cells. Mol Pharm. 2017; 14(12):4648-4660. DOI: 10.1021/acs.molpharmaceut.7b00737. View

Sonawane S, Kalhapure R, Govender T . Hydrazone linkages in pH responsive drug delivery systems. Eur J Pharm Sci. 2016; 99:45-65. DOI: 10.1016/j.ejps.2016.12.011. View

10.

Wu D, Pusuluri A, Vogus D, Krishnan V, Wyatt Shields 4th C, Kim J . Design principles of drug combinations for chemotherapy. J Control Release. 2020; 323:36-46. DOI: 10.1016/j.jconrel.2020.04.018. View

11.

Binauld S, Stenzel M . Acid-degradable polymers for drug delivery: a decade of innovation. Chem Commun (Camb). 2013; 49(21):2082-102. DOI: 10.1039/c2cc36589h. View

12.

Yoon H, Koo H, Choi K, Lee S, Kim K, Kwon I . Tumor-targeting hyaluronic acid nanoparticles for photodynamic imaging and therapy. Biomaterials. 2012; 33(15):3980-9. DOI: 10.1016/j.biomaterials.2012.02.016. View

13.

Long W, Ouyang H, Zhou C, Wan W, Yu S, Qian K . Simultaneous surface functionalization and drug loading: A novel method for fabrication of cellulose nanocrystals-based pH responsive drug delivery system. Int J Biol Macromol. 2021; 182:2066-2075. DOI: 10.1016/j.ijbiomac.2021.05.193. View

14.

Patel A, Sant S . Hypoxic tumor microenvironment: Opportunities to develop targeted therapies. Biotechnol Adv. 2016; 34(5):803-812. PMC: 4947437. DOI: 10.1016/j.biotechadv.2016.04.005. View

15.

Kelly J, Snell M, BERENBAUM M . Photodynamic destruction of human bladder carcinoma. Br J Cancer. 1975; 31(2):237-44. PMC: 2009375. DOI: 10.1038/bjc.1975.30. View

16.

Li H, Du J, Liu J, Du X, Shen S, Zhu Y . Smart Superstructures with Ultrahigh pH-Sensitivity for Targeting Acidic Tumor Microenvironment: Instantaneous Size Switching and Improved Tumor Penetration. ACS Nano. 2016; 10(7):6753-61. DOI: 10.1021/acsnano.6b02326. View

17.

McMahon H, Boucrot E . Molecular mechanism and physiological functions of clathrin-mediated endocytosis. Nat Rev Mol Cell Biol. 2011; 12(8):517-33. DOI: 10.1038/nrm3151. View

18.

Han K, Zhang J, Zhang W, Wang S, Xu L, Zhang C . Tumor-Triggered Geometrical Shape Switch of Chimeric Peptide for Enhanced in Vivo Tumor Internalization and Photodynamic Therapy. ACS Nano. 2017; 11(3):3178-3188. DOI: 10.1021/acsnano.7b00216. View

19.

Wells L, Guo H, Emili A, Sefton M . The profile of adsorbed plasma and serum proteins on methacrylic acid copolymer beads: Effect on complement activation. Biomaterials. 2016; 118:74-83. DOI: 10.1016/j.biomaterials.2016.11.036. View

20.

Li X, Yuan H, Tian X, Tang J, Liu L, Liu F . Biocompatible copper sulfide-based nanocomposites for artery interventional chemo-photothermal therapy of orthotropic hepatocellular carcinoma. Mater Today Bio. 2021; 12:100128. PMC: 8487074. DOI: 10.1016/j.mtbio.2021.100128. View