Neighborhood Disadvantage and Dementia Incidence in a Cohort of Asian American and Non-Latino White Older Adults in Northern California

Overview

Journal Alzheimers Dement

Specialties Neurology
Psychiatry

Date 2022 Apr 7

PMID 35388625

Authors

Taylor M Mobley

Crystal Shaw

Eleanor Hayes-Larson

Joseph Fong

Paola Gilsanz

Gilbert C Gee

Ron Brookmeyer

Rachel A Whitmer

Joan A Casey

Elizabeth Rose Mayeda

Affiliations

Soon will be listed here.

Abstract

Introduction: Some evidence suggests that neighborhood socioeconomic disadvantage is associated with dementia-related outcomes. However, prior research is predominantly among non-Latino Whites.

Methods: We evaluated the association between neighborhood disadvantage (Area Deprivation Index [ADI]) and dementia incidence in Asian American (n = 18,103) and non-Latino White (n = 149,385) members of a Northern California integrated health care delivery system aged 60 to 89 at baseline. Race/ethnicity-specific Cox proportional hazards models adjusted for individual-level age, sex, socioeconomic measures, and block group population density estimated hazard ratios (HRs) for dementia.

Results: Among non-Latino Whites, ADI was associated with dementia incidence (most vs. least disadvantaged ADI quintile HR = 1.09, 95% confidence interval [CI] = 1.02-1.15). Among Asian Americans, associations were close to null (e.g., most vs. least disadvantaged ADI quintile HR = 1.01, 95% CI = 0.85-1.21).

Discussion: ADI was associated with dementia incidence among non-Latino Whites but not Asian Americans. Understanding the potentially different mechanisms driving dementia incidence in these groups could inform dementia prevention efforts.

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