Human Immunodeficiency Virus Type 1 Vif Up-Regulates the Expression of Tat AKT Signaling Pathway: Role of Ubiquitin Specific Protease 17

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2022 Apr 7

PMID 35387085

Authors

Sneh Lata

Vikas Sood

Akhil C Banerjea

Affiliations

Soon will be listed here.

Abstract

Human immunodeficiency virus type 1 (HIV-1) has RNA genome and depends on host cellular machinery for most of its activities. Host cellular proteins modulate the expression and activity of viral proteins to combat the virus. HIV-1 proteins are known to regulate each other for the benefit of virus by exploiting these modulations. Here, we report that HIV-1 Vif increases the levels of Tat AKT signaling pathway. We show that HIV-1 Vif activates AKT signaling pathway by inducing phosphorylation of AKT. Mdm2, downstream target of AKT signaling, increases the levels of Tat protein in ubiquitin-dependent manner by inducing Ubiquitin Specific Protease 17 (USP17), which is a deubiquitinase and stabilizes Tat protein. Thus, HIV-1 proteins exploit AKT signaling pathway to promote viral replication.

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