Species Differences in Regenerative Hyperplasia of Bladder Urothelium After Transurethral Cauterization

Overview

Journal Urol Res

Specialty Urology

Date 1986 Jan 1

PMID 3538609

Authors

H Akaza

K Koseki

T Niijima

Affiliations

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Abstract

The early histological changes in bladder urothelium following transurethral cauterization were sequentially studied in female rats, mice, hamsters and guinea pigs. The changes differed markedly between species: papillary hyperplasia or papilloma in the rats and simple hyperplasia in the mice, hamsters and guinea pigs. The regenerative response to the fulgurative ulcer within a given species was similar to the early response previously observed by others following administration of known bladder carcinogens. This suggests that there may be a regulatory mechanism in the urothelium which is common to urothelial proliferations induced by both carcinogenic and non-carcinogenic stimulations, though differing between animal species.

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