The Yellow Brick Road to Nuclear Membrane Mechanotransduction
Overview
Affiliations
The nuclear membrane may function as a mechanosensory surface alongside the plasma membrane. In this Review, we discuss how this idea emerged, where it currently stands, and point out possible implications, without any claim of comprehensiveness.
Amphipathic helices sense the inner nuclear membrane environment through lipid packing defects.
Lee S, Le Roux A, Mors M, Vanni S, Roca-Cusachs P, Bahmanyar S bioRxiv. 2024; .
PMID: 39605395 PMC: 11601446. DOI: 10.1101/2024.11.14.623600.
Mechanobiology of the cell nucleus.
Lammerding J, Engler A, Kamm R APL Bioeng. 2022; 6(4):040401.
PMID: 36536804 PMC: 9759352. DOI: 10.1063/5.0135299.