Plasma Renin Activity Following Renal Transplantation

Overview

Journal Postgrad Med J

Publisher Oxford University Press

Specialty General Medicine

Date 1978 May 1

PMID 353767

Citations 1

Authors

M H Snow

S J Jachuck

V Robson

R Wilkinson

Affiliations

Soon will be listed here.

Abstract

Plasma renin activity (PRA) was studied serially for up to 21 days following transplantation in thirteen patients receiving renal allografts. PRA was measured during fasting and recumvency and its relationship to renal function, diuretic administration, plasma sodium, allograft rejection and blood pressure was examined. PRA fell steadily as renal function improved and plasma sodium rose following transplantation and when rejection episodes were excluded an inverse relationship between PRA and renal function could be seen. It is not possible to say whether the changes in PRA and function are causally related or whether changes in plasma sodium alone account for the observed changes in PRA. Some rejection episodes were accompanied by an increase in PRA, but this was not sufficiently consistent to be of value in the diagnosis of rejection. PRA also increased in relation to frusemide-induced fluid loss. There was no relationship in these patients between PRA and blood pressure.

Citing Articles

[Change in renin activity and blood pressure in the dog autologous kidney transplant model with modified HTK solution].

Ludwig A, Isemer F, Kallerhoff M, Rumpf K Langenbecks Arch Chir. 1995; 380(2):82-9.

PMID: 7760655 DOI: 10.1007/BF00186413.

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