Obstructive Sleep Apnea As a Risk Factor for Venous Thromboembolism: A Systematic Review

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2022 Apr 4

PMID 35371730

Authors

Rhea Raj

Akil Paturi

Mohamed A Ahmed

Sneha E Thomas

Vasavi Rakesh Gorantla

Affiliations

Soon will be listed here.

Abstract

Obstructive sleep apnea (OSA), is a prevalent condition characterized by repeated episodes of pharyngeal airway obstruction resulting in hypopnea and apnea episodes during sleep leading to nightly awakenings. OSA is a major contributor to the healthcare burden worldwide due to its high cardiovascular morbidity and mortality. There is growing evidence to support a pathophysiological link between OSA and venous thromboembolism (VTE). The pro-inflammatory state along with intermittent hypoxia that is invoked in OSA is associated with blood hypercoagulability, venous stasis, and endothelial dysfunction leading to deep vein thrombosis (DVT) and pulmonary embolism (PE). In this systematic review, we aim to analyze and assess the available literature on OSA and VTE (or DVT/PE) to determine whether OSA is an independent risk factor for VTE.

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