Association of Essential Tremor With Dementia and Affective Disorders: A Meta-Analysis

Overview

Journal Front Neurol

Specialty Neurology

Date 2022 Apr 4

PMID 35370922

Authors

Yajun Shang

Xinjie Chen

MingDa Ai

Xiaoran Gao

Shujuan Dai

Mingjie Zhao

Cen Yang

Liangfeng Wang

Junyan Zhang

Lianmei Zhong

Tianhao Bao

Xiaolei Liu

Affiliations

Soon will be listed here.

Abstract

Background: The dementia and affective disorders are common non-motor features in patients with essential tremor (ET). However, the relationship of ET with cognitive impairments and affective disorders remains controversial. This meta-analysis aimed to analyze the association of ET with dementia and affective disorders.

Methods: Original studies published from January 1999 to October 2019 were systematically searched from the database of Medline (OvidSP), EMBASE (OvidSP), and the Cochrane Central Register of Controlled Trials. Pooled standard mean difference (SMD, random effect model), odds ratios (ORs), relative risk (RR), and 95% were calculated.

Results: Compared with the Non-ET group, patients with ET had significantly lower Mini-Mental State Examination (MMSE) score (, -1.16; , -1.75 to -0.58; = 0.0001) and had significantly higher depressive and anxiety symptoms scale score (, 0.55; , 0.22-0.87; = 0.0009). The OR for dementia and affective disorders in individuals with ET compared with individuals without ET was 2.49 (, 2.17-2.85, < 0.00001). While there was no significant difference in Montreal Cognitive Assessment (MoCA) score between ET and Non-ET groups (, -0.52; , -0.16 to 0.13; = 0.23), there was a significant difference in the risk of mortality between ET and Non-ET groups ( = 4.69, , 2.18-10.07).

Conclusion: The non-motor symptoms should not be neglected among patients with ET. However, the causal relationship between ET and dementia, depression, and anxiety is unclear.

Citing Articles

Analysis of Common Genetic Variation of Anxiety Disorders in Essential Tremor.

Yan Y, Cao L, Gu L, Xu C, Lu J, Lv D J Mol Neurosci. 2025; 75(1):14.

PMID: 39890685 DOI: 10.1007/s12031-024-02226-2.

Cognitive impairment in essential tremor assessed by the cerebellar cognitive affective syndrome scale.

Destrebecq V, Naeije G Front Neurol. 2023; 14:1224478.

PMID: 37662041 PMC: 10473101. DOI: 10.3389/fneur.2023.1224478.

References

Rapoport M, van Reekum R, Mayberg H . The role of the cerebellum in cognition and behavior: a selective review. J Neuropsychiatry Clin Neurosci. 2000; 12(2):193-8. DOI: 10.1176/jnp.12.2.193. View

Louis E, Benito-Leon J, Vega-Quiroga S, Bermejo-Pareja F . Faster rate of cognitive decline in essential tremor cases than controls: a prospective study. Eur J Neurol. 2010; 17(10):1291-7. PMC: 2939209. DOI: 10.1111/j.1468-1331.2010.03122.x. View

Louis E, Benito-Leon J, Vega S, Bermejo-Pareja F . Frailty in elderly persons with essential tremor: a population-based study (NEDICES). Eur J Neurol. 2011; 18(10):1251-7. PMC: 3135673. DOI: 10.1111/j.1468-1331.2011.03374.x. View

Park I, Oh Y, Lee K, Yang D, Song I, Park J . Subtype of mild cognitive impairment in elderly patients with essential tremor. Alzheimer Dis Assoc Disord. 2014; 29(2):141-5. DOI: 10.1097/WAD.0000000000000054. View

Bugalho P, Ladeira F, Barbosa R, Marto J, Borbinha C, Salavisa M . Motor and non-motor function predictors of mortality in Parkinson's disease. J Neural Transm (Vienna). 2019; 126(11):1409-1415. DOI: 10.1007/s00702-019-02055-3. View

Beyer M, Herlofson K, Arsland D, Larsen J . Causes of death in a community-based study of Parkinson's disease. Acta Neurol Scand. 2001; 103(1):7-11. DOI: 10.1034/j.1600-0404.2001.00191.x. View

Koziol L, Budding D, Andreasen N, DArrigo S, Bulgheroni S, Imamizu H . Consensus paper: the cerebellum's role in movement and cognition. Cerebellum. 2013; 13(1):151-77. PMC: 4089997. DOI: 10.1007/s12311-013-0511-x. View

Backstrom D, Granasen G, Domellof M, Linder J, Jakobson Mo S, Riklund K . Early predictors of mortality in parkinsonism and Parkinson disease: A population-based study. Neurology. 2018; 91(22):e2045-e2056. PMC: 6282235. DOI: 10.1212/WNL.0000000000006576. View

Louis E, Benito-Leon J, Vega-Quiroga S, Bermejo-Pareja F . Cognitive and motor functional activity in non-demented community-dwelling essential tremor cases. J Neurol Neurosurg Psychiatry. 2010; 81(9):997-1001. DOI: 10.1136/jnnp.2009.202838. View

10.

Akshoomoff N, Courchesne E, Townsend J . Attention coordination and anticipatory control. Int Rev Neurobiol. 1997; 41:575-98. DOI: 10.1016/s0074-7742(08)60371-2. View

11.

Benito-Leon J, Louis E, Bermejo-Pareja F . Population-based case-control study of cognitive function in essential tremor. Neurology. 2006; 66(1):69-74. DOI: 10.1212/01.wnl.0000192393.05850.ec. View

12.

Fiocco A, Lindquist K, Ferrell R, Li R, Simonsick E, Nalls M . COMT genotype and cognitive function: an 8-year longitudinal study in white and black elders. Neurology. 2010; 74(16):1296-302. PMC: 2860484. DOI: 10.1212/WNL.0b013e3181d9edba. View

13.

Hallett M, Grafman J . Executive function and motor skill learning. Int Rev Neurobiol. 1997; 41:297-323. DOI: 10.1016/s0074-7742(08)60357-8. View

14.

Pinter B, Diem-Zangerl A, Wenning G, Scherfler C, Oberaigner W, Seppi K . Mortality in Parkinson's disease: a 38-year follow-up study. Mov Disord. 2014; 30(2):266-9. DOI: 10.1002/mds.26060. View

15.

Tupler L, Krishnan K, Greenberg D, Marcovina S, Payne M, MacFall J . Predicting memory decline in normal elderly: genetics, MRI, and cognitive reserve. Neurobiol Aging. 2006; 28(11):1644-56. DOI: 10.1016/j.neurobiolaging.2006.07.001. View

16.

Jimenez-Jimenez F, Alonso-Navarro H, Garcia-Martin E, Agundez J . Sleep Disorders in Patients with Essential Tremor. Curr Neurol Neurosci Rep. 2021; 21(5):23. DOI: 10.1007/s11910-021-01109-y. View

17.

Meyers J, Hickman R, Cristal A, Factor-Litvak P, Cosentino S, Louis E . More unaffected first-degree relatives of essential tremor cases have mild cognitive deficits than age-matched controls. Parkinsonism Relat Disord. 2018; 61:144-150. PMC: 6488412. DOI: 10.1016/j.parkreldis.2018.10.030. View

18.

Benito-Leon J, Contador I, Louis E, Cosentino S, Bermejo-Pareja F . Education and risk of incident dementia during the premotor and motor phases of essential tremor (NEDICES). Medicine (Baltimore). 2016; 95(33):e4607. PMC: 5370823. DOI: 10.1097/MD.0000000000004607. View

19.

Thangavelu K, Talk A, Clark G, Dissanayaka N . Psychosocial factors and perceived tremor disability in essential tremor. Neurosci Biobehav Rev. 2019; 108:246-253. DOI: 10.1016/j.neubiorev.2019.10.021. View

20.

Stang A . Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010; 25(9):603-5. DOI: 10.1007/s10654-010-9491-z. View