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Acute Disseminated Encephalitis (ADEM) As the First Presentation of COVID-19; a Case Report

Overview
Publisher Wolters Kluwer
Specialty Medical Education
Date 2022 Apr 4
PMID 35369575
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Abstract

Introduction: and importance: Neurological ailments are reported during and after SARS-COV-2 infection.

Case Presentation: We report a 67-year-old Iranian man with COVID-19 infection and Acute Disseminated Encephalomyelitis (ADEM) whose neurological symptoms appeared before clinical and radiological pulmonary manifestations.

Clinical Discussion: COVID-19 can cause neurological complication without entering the CNS via para infectious inflammatory mechanisms.

Conclusions: This report shows that ADEM might be among primary presentations of COVID-19.

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References
1.
Berger J . COVID-19 and the nervous system. J Neurovirol. 2020; 26(2):143-148. PMC: 7245181. DOI: 10.1007/s13365-020-00840-5. View

2.
Angileri F, Legare S, Marino Gammazza A, de Macario E, Macario A, Cappello F . Molecular mimicry may explain multi-organ damage in COVID-19. Autoimmun Rev. 2020; 19(8):102591. PMC: 7289093. DOI: 10.1016/j.autrev.2020.102591. View

3.
Guan W, Ni Z, Hu Y, Liang W, Ou C, He J . Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020; 382(18):1708-1720. PMC: 7092819. DOI: 10.1056/NEJMoa2002032. View

4.
Abdi S, Ghorbani A, Fatehi F . The association of SARS-CoV-2 infection and acute disseminated encephalomyelitis without prominent clinical pulmonary symptoms. J Neurol Sci. 2020; 416:117001. PMC: 7301801. DOI: 10.1016/j.jns.2020.117001. View

5.
Pezzini A, Padovani A . Lifting the mask on neurological manifestations of COVID-19. Nat Rev Neurol. 2020; 16(11):636-644. PMC: 7444680. DOI: 10.1038/s41582-020-0398-3. View